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BL
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| Record Number
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864045
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| Main Entry
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Gassmann, Oliver,1967-
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| Title & Author
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Leading Pharmaceutical Innovation : : How to Win the Life Science Race /\ Oliver Gassmann, Alexander Schuhmacher, Max von Zedtwitz, Gerrit Reepmeyer.
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| Edition Statement
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Third edition.
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| Publication Statement
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Cham, Switzerland :: Springer,, [2018]
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| Page. NO
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1 online resource
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| ISBN
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3319668331
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: 9783319668338
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3319668323
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9783319668321
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Intro; Preface; Testimonials; Contents; About the Authors; 1: Innovation: Key to Success in the Pharmaceutical Industry; 1.1 The Productivity Paradox; 1.2 The Blockbuster Imperative; Entering the Market Quickly; 1.3 High Risks in Drug Development; Differentiation via Clinical Profiles; 1.4 Outlook; 2: The Industry Challenge: Who Would Want to Be in This Business?; 2.1 A Highly Complex Industry; Industry Classification and Background; Extensive Product Groups; 2.2 Five Forces Analysis of the Drug Industry; Force 1: Bargaining Power of Suppliers; Force 2: Bargaining Power of Buyers.
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3.5 Proteomics and the `-omics ́World3.6 Pharmacogenetics and Pharmacogenomics; 3.7 Computer-Based Drug Discovery; 3.8 Conclusions; 4: The Pipeline Challenge: How to Organize Innovation; 4.1 The Relevance of Pipeline Management; Complexity and Phases of the RandD Process; 4.2 Phases and Checkpoints in the Pharma RandD Process; Case-in-Point: Risk Assessment of a Drug Candidate: Pantoprazole; Stage-Gate and Portfolio Management; 4.3 Portfolio Analysis; Application of a Financial Evaluation of a Project: The Case of Biotech; 4.4 Portfolio Management.
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Case in Point: Mergermania Around Actavis/AllerganMotivations for Pharma MandA; Growth Through Diversification; 2.6 Conclusions; 3: The Science and Technology Challenge: How to Find New Drugs; 3.1 Rise of the Biotechnology Industry: Boosting Innovation; 3.2 The Challenge of Target Discovery; 3.3 High-Throughput Screening: Fail Earlier, Succeed Sooner; Combinatorial Chemistry: Cut Experimental Cycle Times; Hit and Lead Generation Technologies Beyond HTS; 3.4 The Bioinformatics and eHealthcare Revolution; ``Big Data`` and Its Relevance for Pharmaceutical RandD.
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Force 3: Risk of Entry from Potential CompetitorsForce 4: Threat of Substitute Products; Force 5: Rivalry Among Established Companies; Force 6: The Regulators; RandD Regulations; Price Regulations and National Healthcare Systems; Intellectual Property Rights; 2.3 Pressure on the Traditional Pharma Business Model; Continued Rise of Generics/Branded Generics Products; Relevance of Specialty Pharma Drugs; Pressure on Portfolio Optimization; Increasingly Competitive Marketing Efforts; Legal Challenges; 2.4 Growth Drivers for the Years to Come; 2.5 Seeking Salvation in MandA and Diversification.
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Portfolio Decision-Making at Merck Serono S.A.4.5 Conclusions; 5: The Make-or-Buy Challenge: How to In- and Outsource Innovation; 5.1 The Disaggregation of the Pharma Value Chain; 5.2 Outsourcing of Pharmaceutical RandD; Outsourcing Strategy: Captive Offshoring at ALTANA Pharma; AJ Biologics: Successful Partnering of a Vaccine Start-Up; Contract Research Organizations (CROs); Strategic CRO Partners of Pfizer; Managing Outsourcing Activities at Solvias; 5.3 Strategic Research Partnerships; 5.4 In-licensing: Enhancing the Innovation Pipeline; 5.5 Co-development: Benefiting from Joint Resources.
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| Abstract
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This book focuses on three sources of pharmaceutical innovation: new management methods in the drug development pipeline, new technologies as enablers for cutting-edge R & D, and new forms of internationalisation, such as outside-in innovation in the early phases of R & D.
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| Subject
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Drugs-- Research-- Management, Case studies.
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Drugs-- Research-- Management.
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Pharmaceutical industry-- Technological innovations, Case studies.
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Pharmaceutical industry-- Technological innovations.
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BUSINESS ECONOMICS-- Industries-- General.
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Drugs-- Research-- Management.
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Pharmaceutical industry-- Technological innovations.
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Drug Industry-- organization administration.
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Organizational Innovation.
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Pharmaceutical Research-- organization administration.
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| Subject
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Pharmacology, Clinical.
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| Subject
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Technology, Pharmaceutical.
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| Dewey Classification
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338.476151
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| LC Classification
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HD9665.5
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| NLM classification
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2018 G-650
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QV 736.1
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| Added Entry
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Reepmeyer, Gerrit,1976-
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Schuhmacher, Alexander
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Zedtwitz, Maximilian von,1969-
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