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" Resistance to anti-cancer therapeutics targeting receptor tyrosine kinases and downstream pathways / "
Yosef Yarden, Moshe Elkabets, editors.
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BL
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| Record Number
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864075
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| Title & Author
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Resistance to anti-cancer therapeutics targeting receptor tyrosine kinases and downstream pathways /\ Yosef Yarden, Moshe Elkabets, editors.
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| Publication Statement
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Cham, Switzerland :: Springer,, 2018.
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| Series Statement
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Resistance to targeted anti-cancer therapeutics ;; volume 15
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1 online resource
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| ISBN
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3319679325
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: 9783319679327
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3319679309
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9783319679303
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Includes bibliographical references and index.
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| Contents
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Resistance of colorectal tumors to anti-EGFR antibodies -- Resistance of lung cancer to kinase inhibitors specific to EGFR or ALK -- Mechanisms of action and resistance of trastuzumab in breast cancer -- Mechanisms of resistance to molecular therapies targeting the HGF/MET axis -- RAF, MEK and ERK inhibitors as anti-cancer drugs: intrinsic and acquired resistance as a major therapeutic challenge -- Mechanisms of resistance to PI3K and AKT inhibitors -- Sensitivity and resistance to BH3 mimetics in cancer therapy -- Resistance mechanisms to cyclin-dependent kinase inhibitors -- Resistance to inhibitors of angiogenesis.
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| Abstract
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This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.
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Antineoplastic agents.
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Cancer-- Chemotherapy.
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Drug resistance in cancer cells.
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Antineoplastic agents.
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Cancer-- Chemotherapy.
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Drug resistance in cancer cells.
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HEALTH FITNESS-- Diseases-- General.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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Oncology.
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| Dewey Classification
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616.99/4061
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| LC Classification
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RC271.C5
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| Added Entry
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Elkabets, Moshe
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Yarden, Y., (Yosef)
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