| Document Type
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BL
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| Record Number
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864503
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| Title & Author
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Myasthenia gravis and related disorders /\ Henry J. Kaminski, Linda L. Kushner, editors.
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| Edition Statement
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Third edition.
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| Publication Statement
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Cham :: Humana Press,, 2018.
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| Series Statement
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Current clinical neurology
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| Page. NO
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1 online resource :: illustrations (some color)
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| ISBN
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3319735853
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: 9783319735856
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9783319735849
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Intro; Series Editor's Introduction; Preface; Contents; Contributors; 1: Neuromuscular Junction Physiology and Pathophysiology; Introduction; Structural Composition of the Neuromuscular Junction; The Presynaptic Compartment; The Synaptic Cleft; The Postsynaptic Compartment; Normal and Pathological Electrophysiology at the Neuromuscular Junction; Presynaptic Functional Events; Postsynaptic Functional Events; References; 2: Acetylcholine Receptor Structure; Introduction; Size and Shape of AChRs; Structures of AChR Subunits; Organization of Subunits in AChR Subtypes; Acetylcholine-Binding Sites
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Anti-AChR Antibody MeasurementMeasurement of Muscle AChR Concentration; Muscle Histopathology; Electromyography; Acetylcholine Receptor Antibody- Specific Passive Transfer MG (AChR-PTMG); Outcome Measurements for AChR-PTMG; Experimental Humanized Mouse Model (MG-NSG); MG-NSG Protocol; Outcome Measurements for MG-NSG; Health Score; Human Anti-AChR Antibody Measurement; Measurement of Muscle AChR Concentration; Animal Models of MuSK Myasthenia; Active Immunization Models of MuSK Myasthenia (MuSK-EAMG); Passive IgG Transfer Mouse Model of MuSK Myasthenia (MuSK-PTMG)
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Cation Channel and Its GateAntigenic Structure and the Main Immunogenic Region (MIR); Induction of the Autoimmune Response to AChRs in MG; Autoimmune Mechanisms Which Impair Neuromuscular Transmission in MG and EAMG; Effects of AChR Mutations in Congenital Myasthenic Syndromes; Neuronal AChR Subtypes and Functional Roles; Autoimmune Impairment of Neuronal AChRs; Effects of Human Neuronal AChR Mutations; References; 3: Immunopathogenesis of Myasthenia Gravis; Introduction; Heterogeneity of Myasthenia Gravis; Targets of the Autoimmune Response; Typical Features of MG Subtypes; AChR-MG
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MuSK-MG PatientsLRP4-MG Patients; Other Targets; Thymus Pathology; Thymomas; Thymic Follicular Hyperplasia; Effects of Thymectomy; Dysregulation of the Immune System; The Role of B Cells; Treg and Th17 Cells; Follicular Helper T Cells; What Are the Causes of MG?; Contribution of Genetics; Role of the MicroRNA; Triggering Factors; References; 4: Animal Models of Myasthenia Gravis for Preclinical Evaluation; Anti-AChR-Experimental Autoimmune MG (AChR-EAMG); Classical EAMG Mouse Model; Classical AChR-EAMG Rat Model: Induction; Outcome Measurements for AChR-EAMG Models; Health Score
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Outcome Measurements for Rodent Models of MuSK MyastheniaAnimal Care; Rigor of Study Design; References; 5: Epidemiology and Genetics of Myasthenia Gravis; Introduction; Epidemiology of MG; Epidemiology of Antigen Subtypes; AChR Antibody-Positive MG (AChR-MG); MuSK Antibody-Positive MG; LRP4 Antibody-Positive MG; Triple-Seronegative MG (AChR-/MuSK-/LRP4-Antibody Negative); Epidemiology of Clinical Subtypes of MG; Ocular MG; Generalized MG; Thymoma-Associated MG; Treatment-Resistant Ophthalmoplegia; Genetics of Myasthenia Gravis; Non-HLA Genes
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| Abstract
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The third edition of this important, gold-standard title outlines a range of significant advances in the study and understanding of myasthenia gravis. The overarching goal of this new edition is identical to the first and second -- to provide the clinician and the scientist with a common resource for understanding the profound achievements in the clinical, translational, and basic sciences of neuromuscular transmission disorders. In addition to several new authors and an extensive update of all chapters, this third edition includes summaries of pre-clinical research standards for autoimmune MG, along with a broad summary of MG clinical trial performance. The now greater understanding of the clinical presentation of MuSK-related MG and identification of potential new autoantigens, including LRP-4, is discussed. The development of treatment guidelines by groups in Japan, the United Kingdom, Germany, and an international consortium is also outlined. Myasthenia Gravis and Related Disorders, Third Edition, is an invaluable resource for meeting the many and varied needs of clinicians who treat patients with myasthenia gravis.
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| Subject
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Myasthenia gravis-- Pathophysiology.
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| Subject
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Myoneural junction.
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Neuromuscular diseases-- Pathophysiology.
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HEALTH FITNESS-- Diseases-- General.
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Immunology.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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Myoneural junction.
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Neurology clinical neurophysiology.
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Neurosciences.
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| Subject
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Respiratory medicine.
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| Dewey Classification
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616.7/442
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| LC Classification
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RC935.M8
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| Added Entry
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Kaminski, Henry J.
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Kushner, Linda L.
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