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" Targeting trafficking in drug development / "
Alfredo Ulloa-Aguirre, Ya-Xiong Tao, editors.
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BL
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| Record Number
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864601
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| Title & Author
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Targeting trafficking in drug development /\ Alfredo Ulloa-Aguirre, Ya-Xiong Tao, editors.
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| Publication Statement
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Cham, Switzerland :: Springer,, 2018.
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| Series Statement
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Handbook of experimental pharmacology,; volume 245
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| Page. NO
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1 online resource (viii, 425 pages) :: illustrations
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| ISBN
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3319741640
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: 9783319741642
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3319741632
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9783319741635
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| Bibliographies/Indexes
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Includes bibliographical references.
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| Contents
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1. Intracellular trafficking of gonadotropin receptors in health and disease -- 2. Investigating internalization and intracellular trafficking of GPCRs -- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors -- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases -- 5. Pharmacoperones for misfolded gonadotropin receptors -- 6. Pharmacological chaperones: Beyond conformational disorders -- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer -- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches -- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking -- 10. SLC6 transporter folding diseases and pharmacochaperoning -- 11. The molecular physiopathogenesis of islet amyloidosis -- 12. Folding defects leading to primary hyperoxaluria -- 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria.
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| Abstract
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Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.
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| Subject
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Drug development.
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Drug targeting.
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Molecular pharmacology.
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Cellular biology (cytology)
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Drug development.
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Drug targeting.
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MEDICAL-- Pharmacology.
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Molecular pharmacology.
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Pharmacology.
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Drug Delivery Systems.
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Biomedicine.
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Drug Discovery.
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Cell Biology.
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Pharmacology/Toxicology.
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| Dewey Classification
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615.1
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| LC Classification
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RM301.65
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| Added Entry
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Tao, Ya-Xiong
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Ulloa-Aguirre, Alfredo
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