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BL
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| Record Number
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864829
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| Title & Author
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Type IV secretion in gram-negative and gram-positive bacteria /\ Steffen Backert, Elisabeth Grohmann, editors.
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| Publication Statement
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Cham, Switzerland :: Springer,, 2018.
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| Series Statement
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Current topics in microbiology and immunology ;; volume 413
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| Page. NO
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1 online resource
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| ISBN
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3319752413
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: 9783319752419
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3319752405
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9783319752402
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| Bibliographies/Indexes
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Includes bibliographical references.
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| Contents
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Intro; Foreword; T4SS-Then and Now; Contents; Abbreviations; 1 Biological Diversity and Evolution of Type IV Secretion Systems; Abstract; 1 Introduction: The ABC's of T4SS Classification; 2 Function, Structure, and Diversification of T4ASS and T4BSSs; 2.1 The VirD4 Receptor and Its Role in Substrate Selection; 2.2 The Role of Accessory Factors in Substrate Recruitment; 2.3 The Inner Membrane Complex (IMC); 2.4 Evolutionary Adaptations of IMC Subunits; 2.5 The Outer Membrane Core Complex (OMCC); 2.6 Evolutionary Adaptations of OMCC Subunits; 3 T4SS-Mediated Modulation of Target Cell Attachment
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1.1 Transfer Competence Development and Heterogeneity of Isogenic Populations1.2 Bistability and Excitability in Genetic Networks; 1.3 Non-stochastic Switching to Transfer Competence; 1.3.1 Cell-to-Cell Signaling and Quorum Sensing; 1.3.2 Environmental Signals; 1.4 Stochastic Switching: No Signals and Rules, just Random Amplification of Noise?; 1.4.1 Bet Hedging in Bacterial Conjugation; 2 Bacterial DNA Uptake Competence and Transport Mechanisms; 2.1 Principles of DNA Uptake; 2.1.1 DNA Uptake via a T4SS-How to Take up DNA?; 2.1.2 Components of the ComB T4SS of Helicobacter pylori
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2.1.3 Visualization of DNA Uptake in Single Cells of Helicobacter pylori2.2 Competence Development-When to Take up DNA?; 2.2.1 Decision Making for Competence Development Is Species-Specific; 2.2.2 How Is Competence Limited in a T4SS-Mediated DNA Uptake System?; 3 Concluding Remarks; References; 4 Relaxases and Plasmid Transfer in Gram-Negative Bacteria; Abstract; 1 Biochemistry of Relaxases; 2 Relaxase-DNA Binding; 3 Relaxosome; 4 Intracellular Trafficking and Relaxase Recruitment to the Conjugative Pore; 5 Bifunctional Relaxase-DNA Helicase Enzymes; 6 Domain-Specific DNA Interactions
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2.2 Inner Membrane2.2.1 VirB3; 2.2.2 VirB6; 2.2.3 VirB8; 2.3 Outer Membrane and Periplasm; 2.3.1 VirB1; 2.3.2 VirB7 and VirB9; 2.3.3 VirB10; 2.4 Pilus Protein(s); 2.4.1 VirB2; 2.4.2 VirB5; 3 Structures of T4SS Molecular Assemblies; 3.1 The Core (or Outer Membrane) Complex; 3.2 The T4SS3-10 Complex; 3.3 Structure of the Pilus; 4 Mechanism of Substrate Transport; 5 Concluding Remarks; Acknowledgements; References; 3 Prokaryotic Information Games: How and When to Take up and Secrete DNA; Abstract; 1 DNA Secretion by Bacterial Conjugation
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3.1 T4ASS P- and F-pili3.2 Evolutionary Adaptations of T4ASS-Associated Surface Structures; 3.3 T4BSS DNA Transfer and Dot/Icm Systems; 4 Evolution of Dot/Icm Secretion System; 5 Comparisons of Effectors Secreted Through Different Dot/Icm Secretion Systems; 6 Concluding Remarks; Acknowledgements; References; 2 Structural and Molecular Biology of Type IV Secretion Systems; Abstract; 1 Architectures and Functions of Type IV Secretion Systems; 1.1 Classification and Overview; 1.2 Composition of T4SSs; 2 Structures of Individual Components; 2.1 ATPases; 2.1.1 VirB11; 2.1.2 VirD4; 2.1.3 VirB4
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| Abstract
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Type IV secretion systems (T4SSs) are highly versatile membrane-associated transporter machines used by Gram-negative and Gram-positive bacteria to deliver substrate molecules to a large variety of target cells. This volume summarizes our current knowledge of the large variety and structural diversity of T4SSs in pathogenic Escherichia, Agrobacterium, Legionella, Coxiella, Bartonella, Helicobacter, Enterococcus and other species. Divided into 13 chapters contributed by leading experts, it presents findings that significantly enhance our understanding of how various pathogens manipulate host cell functions to trigger bacterial uptake, promote intracellular growth, suppress defense mechanisms and of how bacteria spread antibiotic resistances, thus facilitating bacterial colonization and disease development. The book is an invaluable source of information for researchers and clinicians.
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| Subject
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Gram-negative bacteria-- Secretion.
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Gram-positive bacteria-- Secretion.
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Gastroenterology.
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Immunology.
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Infectious contagious diseases.
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Medical microbiology virology.
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SCIENCE-- Life Sciences-- Biology.
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SCIENCE-- Life Sciences-- Microbiology.
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| Dewey Classification
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579.3/23
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| LC Classification
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QR74.8
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| Added Entry
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Backert, Steffen
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Grohmann, Elisabeth
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