| Document Type
|
:
|
BL
|
| Record Number
|
:
|
865379
|
| Title & Author
|
:
|
Nuclear-cytoplasmic transport /\ Weidong Yang, editor.
|
| Publication Statement
|
:
|
Cham, Switzerland :: Springer,, 2018.
|
| Series Statement
|
:
|
Nucleic acids and molecular biology,; volume 33
|
| Page. NO
|
:
|
1 online resource
|
| ISBN
|
:
|
3319773097
|
|
|
:
|
: 9783319773094
|
|
|
:
|
3319773089
|
|
|
:
|
9783319773087
|
| Contents
|
:
|
Intro; Contents; Chapter 1: Assembly of Nuclear Pore Complex; 1.1 Overview; 1.2 Nups and Subcomplexes of NPCs; 1.3 Assembly of NPCs; 1.3.1 NPC Assembly During Interphase; 1.3.2 Post-Mitotic NPC Assembly; 1.3.3 A Third Pathway for NPC Assembly; 1.4 Regulation of NPC Assembly; 1.5 Conclusions; References; Chapter 2: Structure of Yeast Nuclear Pore Complexes; 2.1 Introduction; 2.1.1 Overall Structure of the NPC; 2.1.2 Difference Between Yeast NPCs and Vertebrate NPCs; 2.2 Stoichiometry of Nups in Yeast NPC; 2.2.1 Recent Progress of the Stoichiometry of Nups by Several Approaches.
|
|
|
:
|
2.2.2 Stoichiometry of Nups in Living Yeast NPCby a Single Molecular Detection Approach2.3 Dynamics of Nups; 2.4 Perspective; References; Chapter 3: Dynamic Structures of the Nuclear Pore Complex and Their Roles in Nucleocytoplasmic Transport; 3.1 Introduction: The NPC Consists of a Rigid Scaffold and Dynamic Peripheral and Central Structures; 3.2 Structural Composition of Dynamic Components of the Nuclear Pore Complex; 3.2.1 The Cytoplasmic Face; 3.2.1.1 Nup358 Is the Major Component of the Cytoplasmic Filaments.
|
|
|
:
|
3.2.1.2 Nup214 and Nup88 Are Components of the Cytoplasmic Ring, not the Filaments3.2.1.3 Nup358/Cytoplasmic Filaments Are Anchored to Nup96 and Nup133 of the Y Complex; 3.2.1.4 Nup358 Is a Multidomain Platform; 3.2.1.5 Nup358 Is Dynamic; 3.2.1.6 Yeast and Plants Have Cytoplasmic Filaments but not Nup358; 3.2.2 FG Domains; 3.2.2.1 Cytosol Is Excluded from an FG Domain-Containing Region Around the NPC Entrance; 3.2.2.2 FG Domains Adopt Alternative Conformations; 3.2.2.3 FG Domains May Form Specific but Dynamic Structures; 3.2.2.4 FG Domains Could Form Dynamic Hydrogel Structures.
|
|
|
:
|
3.2.3 Mapping Transport Routes Suggests the Presence of Defined Central Structures3.2.4 The Nucleoplasmic Face; 3.3 Conclusions; References; Chapter 4: Non-canonical Roles of Nuclear Pore Proteins; 4.1 Introduction: The Nuclear Pore; 4.2 Mitosis: Many Points of Intersection with Nup Function; 4.2.1 Nups and Chromosome Congression; 4.2.2 Nups and Mitotic Spindle Assembly; 4.2.3 Nups and Spindle Assembly Checkpoint Maintenance; 4.2.4 Mitotic Exit and Cytokinesis; 4.3 Regulation of Gene Expression: The Chromatin Landscape and Beyond; 4.4 DNA Damage: Emerging Roles for Nups.
|
|
|
:
|
4.4.1 Nucleoporins and DNA Repair in Yeast4.4.2 Nucleoporins and DNA Repair in Mammalian Cells; 4.5 Pore Proteins at Cilia: Defining Where, Why, and How; 4.6 The NPC as a Signaling and Tethering Platform; 4.7 Further Considerations and Conclusions; References; Chapter 5: On the Role of the Channel Nucleoporins in Nuclear Transport; 5.1 Overview; 5.2 The Channel Nups Are Essential for Significant Nuclear Transport Rates Through the NPC; 5.3 Structural Characterization of the Channel Nups; 5.3.1 X-Ray Structures of the Channel Nups and Implications for Nuclear Transport.
|
| Abstract
|
:
|
Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
|
| Subject
|
:
|
Cytoplasm.
|
| Subject
|
:
|
Nucleoproteins.
|
| Subject
|
:
|
Biochemistry.
|
| Subject
|
:
|
Cytoplasm.
|
| Subject
|
:
|
Evolution.
|
| Subject
|
:
|
Microbiology (non-medical)
|
| Subject
|
:
|
Nucleoproteins.
|
| Subject
|
:
|
SCIENCE-- Life Sciences-- Anatomy Physiology.
|
| Dewey Classification
|
:
|
571.6/5
|
| LC Classification
|
:
|
QH591
|
| Added Entry
|
:
|
Yang, Weidong
|