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BL
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| Record Number
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865888
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| Main Entry
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Lauwereyns, Jan
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| Title & Author
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Rethinking the three R's in animal research : : replacement, reduction, refinement /\ Jan Lauwereyns.
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| Publication Statement
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Cham, Switzerland :: Palgrave MacMillan,, 2018.
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| Page. NO
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1 online resource
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| ISBN
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3319893009
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: 9783319893006
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9783319892993
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Intro; Contents; Chapter 1 Introduction; Abstract; 1.1 Building on the Legacy of Russell and Burch (1959/1992); 1.2 Four Movements to the Argument; 1.3 Full Disclosure; References; Chapter 2 Concept Fatigue with the Three R's; Abstract; 2.1 The Original Work by Russell and Burch (1959/1992) in Context; 2.1.1 On the Removal of Inhumanity; 2.1.2 Humane Versus Speciesist; 2.1.3 The Actual Definitions; 2.1.3.1 Replacement; 2.1.3.2 Reduction; 2.1.3.3 Refinement; 2.2 Changing Perspectives on the Use of Animals; 2.2.1 No Magic Dust; 2.2.2 For the Animal's Sake.
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2.2.3 The Monkey Eye-Movement Paradigm Then and NowReferences; Chapter 3 A Mismatch Between Micro-motives and Macro-behavior; Abstract; 3.1 Analyzing Aggregate Behavior; 3.1.1 Three Classic Examples of Micro-Macro Conflict; 3.1.1.1 The Prisoner's Dilemma; 3.1.1.2 The Tragedy of the Commons; 3.1.1.3 The Case of the Two Dining Rooms; 3.1.2 Applying the Micro-Macro Analysis to Animal Research; 3.1.2.1 The Individual Researcher's Perspective; 3.1.2.2 Failure of the Three R's at the Macroscopic Level; 3.1.2.3 Scale Enlargement for More with Less; 3.1.2.4 Public Support as a Limited Resource.
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3.2 The Principles of Reasonable Experimental Inquiry3.2.1 On the Valuation of Research; 3.2.2 The Preferred Animal Model; 3.2.3 New Definitions; 3.2.3.1 Replacement; 3.2.3.2 Reduction; 3.2.3.3 Refinement; References; Chapter 4 The Monkey Question; Abstract; 4.1 A Critique of Arguments; 4.1.1 The Past Is Not Always a Good Model for the Future; 4.1.2 Misleading Claims of Necessity; 4.1.3 An Erroneous Preference for Nonhuman Primates; 4.1.4 A Prejudice Against Replacement with Other Animals; 4.2 Examples of (Missed) Replacement Opportunities; 4.2.1 Real-Time Control of a Robot Arm.
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4.2.2 Perceptual Decision-Making4.2.3 Cognitive Mechanisms of Cocaine Addiction; References; Chapter 5 Toward Reasonable Experimental Inquiry; Abstract; 5.1 Replacement as the Critical R; 5.1.1 Eyes Open to Opportunity Costs; 5.1.2 Real-World Barriers to Replacement; 5.1.3 A Shift in Agency; 5.2 Practical Wisdom, Informed and Integrative; 5.2.1 Open Science; 5.2.2 Big Science; 5.2.3 Free Thought and Coordinated Action; 5.3 The Sleep of Reason Produces Monsters; References; Index.
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| Abstract
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This work challenges the current reliance on "The Three R's" or Replacement, Reduction and Refinement which direct most animal research in the behavioral sciences. The author argues that these principles that were developed in the 1950's to guide the use of animals in research studies are outdated. He suggests that the notions of refinement and reduction are often ill-defined and can be useful only in cases where replacement is impossible.
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| Subject
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Laboratory animals-- Research.
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Medicine-- Research.
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Laboratory animals-- Research.
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Medicine-- Research.
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TECHNOLOGY ENGINEERING-- Agriculture-- Animal Husbandry.
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| Dewey Classification
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636.0885
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| LC Classification
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QL55
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