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BL
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| Record Number
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865893
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| Main Entry
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Thiriet, Marc
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| Title & Author
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Vasculopathies : : behavioral, chemical, environmental, and genetic factors /\ Marc Thiriet.
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| Publication Statement
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Cham, Switzerland :: Springer,, [2018]
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, ©2018
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| Series Statement
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Biomathematical and biomechanical modeling of the circulatory and ventilatory systems,; volume 8
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| Page. NO
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1 online resource
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| ISBN
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3319893149
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: 3319893157
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: 3319893165
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: 9783319893143
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: 9783319893150
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: 9783319893167
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9783319893143
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| Contents
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Intro; Preface; Organ and Physiological Apparatus; Blood Flow; Gas Transport; Modeling; Mechanical Investigations; Book Series; Book Organization; Acknowledgments; Contents; 1 Cardiovascular Disease: An Introduction; 1.1 Vasculopathies and Vasculitides; 1.1.1 Ethnic Differences; 1.1.2 Gender Influence; 1.1.2.1 Estrogen Signaling; 1.1.2.2 Androgen Signaling; 1.1.2.3 Enzymes of Steroid Hormone Metabolism; 1.1.3 Vasculitis (Angiitis); 1.1.4 Vascular Wall Disorders; 1.1.4.1 Hemostasis and Thrombosis; 1.1.4.2 Inflammation and Angiogenesis; 1.1.4.3 Oxidative and Nitrosative Stresses; 1.1.4.4 Aging
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1.1.4.5 Sleep Disorders1.1.4.6 Vascular Tumors and Malformations; 1.1.4.7 Ectopic Vascular Calcification; 1.1.5 Atherosclerosis; 1.2 Vasculopathies and Cardiac Dysfunction; 1.2.1 Cardiac Wall Remodeling; 1.2.1.1 Cardiac Wall Hypertrophy; 1.2.1.2 Cardiac Wall Fibrosis; 1.2.2 Cardiomyocyte Remodeling; 1.2.2.1 Energy Metabolism; 1.2.2.2 Ion Carriers; 1.2.2.3 Transverse Tubules; 1.2.2.4 Mitochondrion; 1.2.3 Altered Signaling; 1.2.4 Interrelation Between the Heart and Kidney; 1.2.5 Ectopic Calcification; 1.3 Autoimmune Disorders; 1.4 Congenital Vascular Malformations
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2 Cardiovascular Risk Factors and Markers2.1 Environmental Stressors; 2.1.1 Air Pollution; 2.1.1.1 Airborne Pollutants; 2.1.1.2 Determinants of Air Pollution Exposure; 2.1.1.3 Aerosol Classification; 2.1.1.4 Air Filtration; 2.1.1.5 Biological Mechanisms; 2.1.1.6 Cardiovascular Events; 2.1.2 Noise; 2.2 Transcripts; 2.2.1 MicroRNAs; 2.2.1.1 Endothelial Mechanical Stress-Responsive MicroRNAs; 2.2.1.2 Regulators of Vascular Smooth Myocyte Phenotype; 2.2.1.3 Platelet MicroRNAs; 2.2.1.4 Hepatic MicroRNAs Operating in Metabolism; 2.2.1.5 MicroRNAs and Mitochondrial Function and Dysfunction
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2.2.1.6 MicroRNAs as Risk Markers2.2.1.7 MicroRNAs Involved in Adverse Cardiac Remodeling; 2.2.1.8 MicroRNAs in Obesity and Diabetes; 2.2.1.9 MicroRNAs Involved in Atherosclerosis; 2.2.1.10 MicroRNAs Involved in Stroke; 2.2.2 Circular RNAs; 2.2.3 YRNAs; 2.2.4 Long Nonprotein-Coding RNAs; 2.2.4.1 Endothelial Long Nonprotein-Coding RNAs; 2.2.4.2 Long Nonprotein-Coding RNAs and Mitochondrial Function; 2.2.4.3 Long Nonprotein-Coding RNAs in Adverse Cardiac Remodeling; 2.2.5 Ribosomal RNA; 2.3 Clinical Types of Markers; 2.3.1 Screening; 2.3.1.1 Hemostasis Factors; 2.3.1.2 Periodontitis
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| Abstract
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This volume presents one of the clinical foundations of vasculopathies: the biological markers and risk factors associated with cardiovascular disease. A detailed biological and clinical framework is provided as a prerequisite for adequate modeling. Chapter 1 presents cardiovascular risk factors and markers, where the search for new criteria is aimed at improving early detection of chronic diseases. The subsequent chapters focus on hypertension, which involves the kidney among other organs as well as many agents, hyperglycemia and diabetes, hyperlipidemias and obesity, and behavior. The last of these risk factors includes altered circadian rhythm, tobacco and alcohol consumption, physical inactivity, and diet. The volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in anatomical conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning in quantitative terms.
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| Subject
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Blood-vessels-- Diseases.
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Cardiology.
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Blood-vessels-- Diseases.
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Cardiology.
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HEALTH FITNESS-- Diseases-- General.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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Biological and Medical Physics, Biophysics.
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Biomedical Engineering and Bioengineering.
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Cardiology.
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Engineering Fluid Dynamics.
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Mathematical and Computational Biology.
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| Subject
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Systems Biology.
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| Dewey Classification
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616.13
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| LC Classification
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RC691
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