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BL
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| Record Number
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865987
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| Title & Author
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Precision molecular pathology of neoplastic pediatric diseases /\ Larissa V. Furtado, Aliya N. Husain, editors.
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| Publication Statement
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Cham, Switzerland :: Springer,, 2018.
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| Series Statement
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Molecular pathology library,
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| Page. NO
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1 online resource
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| ISBN
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3030078183
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: 3319896261
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: 331989627X
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: 9783030078188
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: 9783319896267
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: 9783319896274
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3319896253
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9783319896250
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| Notes
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Includes index.
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| Contents
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Intro; Contents; Contributors; Part I: Molecular Pathology of Pediatric Neoplasms: General Principles; Chapter 1: Principles of Molecular Biology and Oncogenesis; Principles of Molecular Biology; Nucleic Acid Structure, Composition, and Organization; Gene Structure, Organization, and Expression; Chromosome Structure; Mitochondrial DNA; Principles of Oncogenesis; Oncogenes; Tumor Suppressor Genes; References; Chapter 2: Molecular Methods in Oncology: Targeted Mutational Analysis; PCR-Based Techniques; Overview; Background; Method; Template; Primers; Polymerase; Procedure.
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Advantages/DisadvantagesAdvantages; Disadvantages; Applications; Variations; Reverse Transcriptase PCR (RT-PCR); Real-Time PCR/Quantitative PCR (qPCR); Nested PCR; Multiplex PCR; Allele-Specific PCR (ASPCR); Digital PCR (dPCR); Methylation-Specific PCR; Fluorescence In Situ Hybridization (FISH); Overview; Background; Method; Probes; Targets; Procedure; Signals and Detection; Advantages and Disadvantages; Advantages; Disadvantages; Applications; Chromosomal Aneusomies; Segmental Deletions; Single Gene Amplification; Translocations; Other Clinically Relevant FISH Variants; References.
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Chapter 3: Molecular Methods in Oncology: Genomic AnalysisNext-Generation Sequencing; Overview; Background; Methods; Next-Generation Sequencing (NGS); Solexa/Illumina; Ion Semiconductor Sequencing; Single-Molecule Real-Time (SMRT) Sequencing; Sequencing by Oligonucleotide Ligation and Detection (SOLiD); Data Analysis; Applications; Chromosomal Microarray; Overview; Background; Methods; General Principles; Comparative Genomic Hybridization (CGH); DNA Sequence Analysis; Gene Expression Profiling; Advantages and Disadvantages; Applications; References.
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Chapter 4: Molecular Testing in Pediatric Oncology PracticeIntroduction; Indications for Molecular Testing; Diagnosis; Prognosis; Therapeutic Guidance; Disease Status Monitoring; Inherited Susceptibility; Specimens for Molecular Testing; Peripheral Blood; Bone Marrow; Tissue; Cytology Specimens; Acellular Body Fluids; Buccal Swab/Saliva; Skin/Fibroblast Culture; Specimen Collection/Handling Procedures; Selecting the Appropriate Molecular Test; What Is the Test Purpose?; What Are the Possible Specimen Options?; What Are the Available Test Options?
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How Does the Clinical Scenario Impact the Decision?Interpretation and Integration of Test Results; Ethical Considerations in Pediatric Genomic Oncology Testing; References; Chapter 5: Molecular Targeted Therapy of Pediatric Neoplasms; Introduction; Mechanisms to Identify Potential Targets; Mechanisms to Target Cancer Cells; Metabolic Differences; Asparaginase; Methotrexate; DFMO; Aberrant Signaling; Tyrosine Kinase Inhibitors; Imatinib, Dasatinib; Ruxolitinib; Pazopanib; WEE1 Inhibitor; Serine/Threonine Kinase Inhibitors; Everolimus; Temsirolimus; Targeting Restricted Protein Expression.
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| Abstract
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This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care. Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.
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| Subject
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Tumors in children-- Molecular aspects.
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HEALTH FITNESS-- Diseases-- General.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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Medicine.
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Oncology.
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Oncology.
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Pathology.
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Pathology.
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| Dewey Classification
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616.92/994
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| LC Classification
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RC281.C4
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| Added Entry
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Furtado, Larissa V.
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Husain, Aliya N.
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