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BL
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| Record Number
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866066
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| Title & Author
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Nanooncology : : engineering nanomaterials for cancer therapy and diagnosis /\ Gil Gonçalves, Gerard Tobias, editors.
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| Publication Statement
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Cham, Switzerland :: Springer,, 2018.
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| Series Statement
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Nanomedicine and nanotoxicology,
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| Page. NO
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1 online resource (vi, 455 pages) :: illustrations (some color)
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| ISBN
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3319898779
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: 3319898787
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: 9783319898773
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: 9783319898780
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9783319898773
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| Contents
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Intro; Contents; Gold Nanoparticles for Imaging and Cancer Therapy; 1 Introduction; 2 Synthesis of Gold Nanoparticles for Biomedical Applications; 2.1 Direct Reduction: The Turkevitch Method; 2.2 Seed-Mediated Growth for Smaller and Narrower Particle Size Distributions; 2.3 Syntheses Taking Place in Organic Media; 2.4 Au NPs Purification Prior to Coatings and Functionalization; 2.5 Ligand-Free Au NP Suspensions; 2.6 Surface Treatment of Au NPs; 2.7 Cell Toxicity of Au NPs: In Vitro Studies; 3 Principles of Physical Interactions Between Photons and High-Z Elements.
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2.4 Limitations and Future Perspectives3 Carbon Quantum Dots; 3.1 CDs for Cancer Bioimaging; 3.2 CDs for Cancer Therapy; 4 Silicon Quantum Dots; 4.1 Silicon Quantum Dots for Bioimaging Applications; 4.2 Silicon Quantum Dots for Drug Delivery and Cancer Therapy; 5 Black Phosphorus Quantum Dots (BP QDs); 6 Germanium Quantum Dots (Ge QDs); 7 Semiconducting Polymer Dots; 7.1 Cancer Cell-Specific Imaging and in Vivo Tumor Imaging; 7.2 Pdots-Based Cancer Therapy; 7.3 Non-conjugated Pdots and Their Biomedical Applications; 8 Final Remarks and Future Perspective; References.
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4 Impact of Radiation and Au-Mediated Radiosensitization Products on Cells and Tissues4.1 The Physical Phase; 4.2 The Chemical Phase; 4.3 Measurement of Physical and Chemical Impact of Au NPs on DNA; 4.4 The Biological Phase; 5 Performance of Au NPs as X-Ray Computed Tomography Contrast Agents; 5.1 Attenuation of X-Rays by High-Z Elements; 5.2 Conventional Iodinated Contrast Agents; 5.3 Blood-Pool Contrast Agents; 5.4 Au-Based Blood-Pool Agents; 6 Performance of Gold Nanoparticles as Radiosensitizers in Oncology; 6.1 Main Mechanisms of Radiosensitization.
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6.2 Au NPs as Radiosensitizers in External Beam Therapy6.3 Dose Simulations Have Confirmed a Good Match Between Au NPs and Brachytherapy Sources; 6.4 Radioactive Au NPs; 6.5 Current Status of Au NPs as Radiosensitizers for Clinical Applications; 7 Biodistribution, Clearance and in Vivo Toxicity; 7.1 Biodistribution and Clearance Routes of Gold Nanoparticles; 7.2 The Intravascular Injection Route; 7.3 The Intratumoral Injection Route; 7.4 In Vivo Toxicity Studies; 8 Perspectives: Current Status of Au NPs in Clinical Trials; 9 Conclusion; References.
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Liposomes-Based Nanoparticles for Cancer Therapy and Bioimaging1 Introduction; 1.1 Liposome Composition; 2 Cancer Therapy; 2.1 Drug Delivery System; 2.2 Liposomes in Gene Delivery; 2.3 Targeted Delivery; 3 Bioimaging; 3.1 Image-Guided Drug Delivery; 4 Conclusion; References; Quantum Dots for Cancer Therapy and Bioimaging; 1 Semiconductor Quantum Dots; 1.1 QDs for Tumor Imaging; 1.2 QDs in Cancer Therapy; 1.3 Limitations and Future Perspectives; 2 Silver Chalcogenide Quantum Dots; 2.1 Silver Sulfide (Ag2S) QDs; 2.2 Silver Selenide (Ag2Se) QDs; 2.3 Silver Telluride (Ag2Te) QDs.
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| Abstract
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This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.
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| Subject
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Nanomedicine.
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Oncology-- Technological innovations.
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Nanomedicine.
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Neoplasms-- therapy.
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Biomedical engineering.
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HEALTH FITNESS-- Diseases-- General.
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Materials science.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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Nanomedicine.
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Nanotechnology.
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Oncology.
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Pharmacology.
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| Dewey Classification
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616.99/4
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| LC Classification
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RC254.5
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| NLM classification
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QZ 266
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| Added Entry
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Gonçalves, Gil
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Tobias, Gerard
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