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" Cerebral ischemic reperfusion injuries (CIRI) : "
Weijian Jiang, Wengui Yu, Yan Qu, Zhongsong Shi, Benyan Luo, John H. Zhang, editors.
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BL
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| Record Number
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866162
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| Title & Author
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Cerebral ischemic reperfusion injuries (CIRI) : : bench research and clinical implications /\ Weijian Jiang, Wengui Yu, Yan Qu, Zhongsong Shi, Benyan Luo, John H. Zhang, editors.
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| Publication Statement
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Cham, Switzerland :: Springer,, 2018.
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| Series Statement
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Springer series in translational stroke research,
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1 online resource (xvii, 259 pages) :: illustrations (some color)
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| ISBN
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331990194X
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: 9783319901947
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3319901931
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9783319901930
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| Contents
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Intro; Preface; Introduction; Recanalization-Related Injury; Safety andEfficacy ofLate Recanalization; The Application ofNew Imaging Technique andStrategies; The Characteristics ofPosterior Circulation Stroke; The Immune Regulation andStroke; The Cerebral Venous System andStroke; Contents; About the Editors; Chapter 1: Gelatinase-ƯMediated Impairment ofMicrovascular Beds inCerebral Ischemia andReperfusion Injury; 1 Introduction; 2 Microvascular Beds andtheExtracellular Matrix (ECM); 3 Gelatinases Mediate Impairment ofMicrovascular Beds inCIRI.
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1.2.1 Brain-Blood Barrier Permeability1.2.2 Postischemic Hyperperfusion; 2 Infarct Growth; 2.1 Mechanisms; 2.1.1 Apoptosis; 2.1.2 Neutrophil Infiltration andImmune Inflammation; 2.2 Predictive Imaging Markers; 2.2.1 No-Reflow Phenomenon; 2.2.2 Cerebral Neutrophil Recruitment; 2.2.3 Vascular Inflammation; 2.2.4 Postischemic Hyperperfusion; 3 Brain Edema; 3.1 Mechanisms andEdema Types; 3.1.1 Brain-Blood Barrier Damage andVasogenic Edema; 3.1.2 Postischemic Hyperperfusion andCytotoxic Edema; 4 Treatments; 4.1 Ischemic Conditioning Therapy; 4.1.1 Ischemic Preconditioning Therapy.
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2.3.5 Pyroptosis3 Artery Recanalization ofIschemic Stroke; 3.1 Intravenous Thrombolytic andAntiplatelet Therapy Treatment; 3.2 Endovascular Treatment forAcute Ischemic Stroke; 3.3 Antioxidant andOther Treatment; 4 Reperfusion Injury After Artery Recanalization; 5 Conclusion; References; Chapter 3: Cerebral Ischemic Reperfusion Injury (CIRI) Cases; 1 Case Description; 2 Discussion; References; Chapter 4: CIRI After Early Recanalization; 1 Hemorrhage Transformation (HT); 1.1 Mechanisms; 1.1.1 Oxidative Stress; 1.1.2 Neurovascular Unit Injury; 1.2 Predictive Imaging Markers.
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4 Activation ofGelatinases andExtravasation oftPA intoBrain Parenchyma inCIRI-Induced Microvascular Bed Damage5 Early Inhibition ofGelatinases May Escalate Neuroprotection andExtend thetPA Therapeutic Window; References; Chapter 2: Characters ofIschemic Stroke andRecanalization Arteries; 1 Introduction; 2 Characters oftheIschemic Stroke; 2.1 Epidemiology andRisk Factors ofIschemic Stroke; 2.2 The Imaging andDiagnosis ofIschemic Stroke; 2.3 The Pathophysiology ofIschemic Stroke; 2.3.1 Excitotoxicity; 2.3.2 Inflammatory Response; 2.3.3 Apoptosis; 2.3.4 Autophagy.
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4.1.2 Ischemic Postconditioning Therapy4.2 Immunosuppressive Agents; 4.3 Hypothermia Treatment; 5 Conclusion; References; Chapter 5: Programmed Cell Death inCIRI; 1 Introduction; 2 Apoptotic Cell Death inCIRI; 2.1 Molecular Biology Mechanism ofApoptosis AfterIschemic Stroke; 2.1.1 Molecules Related toApoptosis ofNeurons; Caspase Family; B-Cell Leukemia/Lymphoma 2 (Bcl-2) Family; Tumor Necrosis Factor Receptor (TNFR) Superfamily; Other Molecules; 2.2 Pathways Related toApoptosis ofCIRI; 2.2.1 Intrinsic Pathway; 2.2.2 Extrinsic Pathway; 2.3 Significance ofApoptosis inCIRI.
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| Abstract
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This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi'an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.
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Cerebral ischemia.
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Reperfusion injury.
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Cerebral ischemia.
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HEALTH FITNESS-- Diseases-- General.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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Reperfusion injury.
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Brain Ischemia.
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Reperfusion Injury.
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| Dewey Classification
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616.8/1
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| LC Classification
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RC388.5
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| Added Entry
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Jiang, Weijian
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Luo, Benyan
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Qu, Yan
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Shi, Zhongsong
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Yu, Wengui
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Zhang, J. H., (John H.)
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