| Document Type
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BL
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| Record Number
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866188
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| Title & Author
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Voltage-gated sodium channels : : structure, function and channelopathies /\ Mohamed Chahine editor.
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| Edition Statement
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[update and expanded edition]
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| Publication Statement
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Cham, Switzerland :: Springer,, 2018.
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| Series Statement
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Handbook of Experimental Pharmacology ;; volume 246
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| Page. NO
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1 online resource :: illustrations (some color).
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| ISBN
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3319902830
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: 3319902849
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: 9783319902838
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: 9783319902845
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9783319902838
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Preface -- Part I -- Evolution of voltage-gated sodium channels -- 1. Evolutionary History of Voltage-Gated Sodium Channels -- 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. -- Part II. The structural basis of sodium channel function -- 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective -- 4. The Cardiac Sodium Channel and Its Protein Partners -- 5. : Posttranslational Modification of Sodium Channels -- 6. Sodium Channel Trafficking -- 7. pH Modulation of Voltage-Gated Sodium Channels -- 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C -- Part III. Drugs and toxins interactions with sodium channels -- 9. Toxins That Affect Voltage-Gated Sodium Channels -- 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels -- 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels -- 12. Structural Models of Ligand-Bound Sodium Channels -- 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7 -- Part IV. Pathophysiology of sodium channels -- 14. Sodium Channelopathies of Skeletal Muscle -- 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction -- 16. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain -- 17. Gating Pore Currents in Sodium Channels -- 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells -- 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases. .
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| Subject
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Sodium channels.
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| Subject
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SOCIAL SCIENCE / Anthropology / Physical.
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| Subject
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Sodium channels.
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| Subject
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Voltage-Gated Sodium Channels.
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| Subject
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Channelopathies-- physiopathology.
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| Subject
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Sodium Channels-- physiology.
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| Dewey Classification
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573.848
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| LC Classification
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QP356.2.V65 2018
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| Added Entry
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Chahine, Mohamed
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