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" Nuclear architecture and dynamics / "
edited by Christophe Lavelle, Jean-Marc Victor.
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BL
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| Record Number
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872338
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| Title & Author
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Nuclear architecture and dynamics /\ edited by Christophe Lavelle, Jean-Marc Victor.
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| Publication Statement
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London :: Academic Press,, [2018]
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, ©2018
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| Series Statement
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Translational epigenetics series ;; v. 2
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| Page. NO
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1 online resource :: illustrations
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| ISBN
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012803503X
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: 9780128035030
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0128034807
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9780128034804
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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DNA mechanics -- The role of nucleosome positioning in genome function and evolution -- DNA supercoiling(omics) -- Dynamic chromatin folding in the cell -- Mesoscale modeling of chromatin fibers -- A polymer physics view on universal and sequence-specific aspects of chromosome folding -- Persistence of long-range contacts at insulators: turnover dynamics or engage cohesion? -- Long-range intranuclear interactions -- The multiple effects of molecular crowding in the cell nucleus: from molecular dynamics to the regulation of nuclear architecture -- Nuclear bodies -- Nucleolus: the consummate nuclear body -- Transcription factories as spatial and functional organization nodes -- Polycomb bodies -- The nuclear lamina and genome organization -- Actin in the cell nucleus -- Nuclear pores and the genome -- Protein transport between the nucleus and cytoplasm -- Replicating chromatin in the eukaryotic genome -- Promoter-enhancer looping and regulatory neighborhoods: gene regulation in the framework of topologically associating domains -- Sailing the Hi-C's: benefits and remaining challenges in mapping chromatin interactions -- Chromatin folding and recombination -- Altered nucleus and disease -- Yeast nucleus: a model for chromatin folding principles -- Chromosomes and chromatin in the nematode nucleus -- Nuclear dynamics at specific cell cycle stages in the slime mold Physarum polycephalum.
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| Abstract
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Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines.
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| Subject
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Cell nuclei.
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Cell nuclei.
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SCIENCE-- Life Sciences-- Biology.
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Cell Nucleus.
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Genome.
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| Dewey Classification
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574.8732
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| LC Classification
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QH595.N8 2018eb
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| NLM classification
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2018 C-484
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QU 350
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| Added Entry
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Lavelle, Christophe
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Victor, Jean-Marc
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