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" Meselson, Stahl, and the replication of DNA : "
Frederic Lawrence Holmes.
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BL
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| Record Number
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875642
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| Main Entry
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Holmes, Frederic Lawrence.
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| Title & Author
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Meselson, Stahl, and the replication of DNA : : a history of "the most beautiful experiment in biology" /\ Frederic Lawrence Holmes.
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| Publication Statement
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New Haven, CT :: Yale University Press,, 2001.
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| Page. NO
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1 online resource (xii, 503 pages) :: illustrations
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| ISBN
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0300129661
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: 1281730459
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: 9780300129663
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: 9781281730459
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0300085400
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9780300085402
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| Bibliographies/Indexes
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Includes bibliographical references (pages 449-496) and index.
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| Contents
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Contents -- Preface -- Acknowledgments -- Introduction -- The Replication Problem -- Meselson and Stahl -- Twists and Turns -- Crossing Fields: Chemical Bonds to Biological Mutants -- Dense Solutions -- The Big Machine -- Working at High Speed -- The Unseen Band -- One Discovery, Three Stories -- An Extremely Beautiful Experiment -- Centrifugal Forces -- The Subunits of Semiconservative Replication -- Images of an Experiment -- Afterword -- Abbreviations Used in Notes -- Notes -- Index
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| Abstract
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In 1957 Matthew Meselson and Frank Stahl produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a 'most beautiful' experiment whose beauty was tied to its simplicity. This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research - its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty.
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Meselson, Matthew.
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Stahl, Franklin W.
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Meselson, Matthew Stanley, 1930-
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Meselson, Matthew Stanley.
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Meselson, Matthew.
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Stahl, Franklin W.
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Stahl, Franklin William, 1929-
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Stahl, Franklin William.
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| Subject
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DNA replication-- Experiments-- History.
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Molecular biology-- Experiments-- History.
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DNA Replication.
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Molecular Biology-- history.
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Meselson-Stahl-Experiment
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Molecular biology-- Experiments.
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Replikation
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SCIENCE-- History.
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SCIENCE-- Life Sciences-- Genetics Genomics.
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DNA.
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Replicatie (biochemie)
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| Dewey Classification
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572.8/6
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| LC Classification
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QP624.H654 2001eb
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| NLM classification
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2002 A-756
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QU 11.1H749m 2001
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42.13bcl
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WB 2405rvk
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