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BL
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| Record Number
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877860
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| Title & Author
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Templated DNA nanotechnology : : functional DNA nanoarchitectonics /\ edited by Thimmaiah Govendaraju.
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| Publication Statement
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Singapore :: Pan Stanford Publishing,, [2019]
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| Page. NO
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1 online resource (1 volume) :: illustrations
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| ISBN
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0429428669
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: 042976765X
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: 0429767668
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: 0429767676
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: 9780429428661
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: 9780429767654
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: 9780429767661
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: 9780429767678
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9789814800211
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981480021X
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Cover; Half Title; Title Page; Copyright Page; Table of Contents; Preface; 1: Multichromophore Stacks in DNA: Novel light-Harvesting Systems; 1.1 Introduction; 1.2 Covalent DNA-Chromophore Architectures: Facile Sequence Control; Challenging Synthesis; 1.2.1 Chromophores as Nucleoside Surrogates; 1.2.2 Chromophores as Nucleobase Surrogates; 1.2.3 Modification of the 2' -Position; 1.2.4 Modification of the DNA Base; 1.3 Supramolecular DNA-Chromophore Architectures: Challenging Sequence Control; Facile Synthesis; 1.4 Conclusion
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2.4 Analytical Methods to Purify and Characterize DNS-Organic Hybrid Monomers and Nanostructures2.4.1 Gel Electrophoresis; 2.4.1.1 Agarose gel electrophoresis; 2.4.1.2 Polyacrylamide gel electrophoresis; 2.4.2 HPLC; 2.4.3 ESI-MS; 2.4.4 MALDI-TOF; 2.4.5 AFM; 2.4.6 TEM; 2.5 Role of Synthetic Molecules in DNA-Assembled Structures; 2.5.1 Organic Molecules as Linkers; 2.5.2 Organic Molecules as Charge Injectors in DNA; 2.5.3 Organic Molecule-DNA Monomers for Templated Polymerization; 2.5.4 Organic Molecules and Nanoparticles for Light Harvesting
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2.5.5 Antibacterial, Biosensing, and Miscellaneous Functions2.5.6 Synthetic Molecules Used in Molecular Electronics; 2.6 Self-Assembly as a Tool to Engineer DNA-Programmed Nanostructures from a DNA-Monomer Hybrid; 2.7 Conclusions; 3: Functional Molecule-Templated DNA Nanoarchitectures; 3.1 Introduction; 3.2 Perspective: Small Molecule and DNA Hybrid Ensemble; 3.3 Templated DNA Nanoarchitectures Via Canonical Hydrogen-Bonding Interaction; 3.4 Templated DNA Nanoarchitectures Via Noncanonical Hydrogen-Bonding Interaction; 3.5 Templated DNA Nanoarchitectures Via Ionic Interaction
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2: DNA-Programmed Nanoscale Assemblies of Covalently Linked Functional Monomers2.1 Introduction: DNA-Programmed Assemblies; 2.2 DNA-Synthetic Molecule Hybrid for Supramolecular DNA Nanotechnology; 2.2.1 Advantages of Covalent Conjugation of Molecules with DNA; 2.3 Conjugation Strategies; 2.3.1 DNA Synthesizer-Based Insertion; 2.3.1.1 Advantages and disadvantages of synthesizer-based insertion; 2.3.2 Postsynthetic Modifications; 2.3.2.1 Amine-phosphate coupling; 2.3.2.2 Carboxylic acid-amine coupling; 2.3.2.3 Thiol-based coupling; 2.3.2.4 Click chemistry
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3.6 Templated DNA Nanoarchitecture Via Metal-Base Pair Interaction3.7 Conclusions and Future Perspectives; 4: Functional DNA Amphiphiles; 4.1 Introduction; 4.2 Self-Assembly of Amphiphiles; 4.3 DNA-Based Amphiphiles; 4.4 Different Types of DNA Amphiphiles; 4.5 Synthesis of DNA Amphiphiles; 4.5.1 Solution Phase Synthesis; 4.5.2 Solid Phase Synthesis; 4.5.3 Other Approaches for the Synthesis of DNA Amphiphiles; 4.6 Self-Assembly of DNA Amphiphiles; 4.6.1 Micellar (Spherical and Cylindrical) Nanostructures; 4.6.2 Vesicular Nanostructures; 4.6.3 Other DNA Nanostructure
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| Abstract
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Nucleic acids have structurally evolved over billions of years to effectively store and transfer genetic information. In the 1980s, Nadrian Seeman's idea of constructing a 3D lattice from DNA led to utilizing DNA as nanomolecular building blocks to create emergent molecular systems and nanomaterial objects. This bottom-up approach to construct nanoscale architectures with DNA marked the beginning of a new field, DNA nanotechnology, contributing significantly to the broad area of nanoscience and nanotechnology. The molecular architectonics of small "designer" molecules and short DNA sequences through complementary binding interaction engenders well-defined functional nanoarchitectures with realistic applications in areas ranging from biology to materials science and is termed "DNA nanoarchitectonics." This book discusses novel approaches adapted by leading researchers from all over the world to create functional nucleic acid molecular systems and nanoarchitectures. Individual chapters contributed by active practitioners provide fundamental and advanced knowledge emanated from their own and others' work. Each chapter includes numerous illustrations, historical perspectives, case studies and practical examples, critical discussions, and future prospects. This book can serve as a practical handbook or as a textbook for advanced undergraduate- and graduate-level students of nanotechnology and DNA nanotechnology, supramolecular chemistry, and nanoarchitectonics and researchers working on macromolecular science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in sensors, biosensors, nanoswitches and nanodevices, diagnostics, drug delivery, and therapeutics.
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DNA.
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Nanotechnology.
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DNA.
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Nanotechnology.
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SCIENCE-- Life Sciences-- Biochemistry.
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TECHNOLOGY-- Material Science.
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| Dewey Classification
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572.86
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| LC Classification
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QH465.D55
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| Added Entry
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Govindaraju, Thimmariah
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| Parallel Title
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Templated Deoxyribonucleic acid nanotechnology
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: Functional DNA nanoarchitectonics
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