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" Transactions on large-scale data- and knowledge-centered systems XXXVIII : "
Abdelkader Hameurlain, Roland Wagner, Sven Hartmann, Hui Ma (eds.).
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AL
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| Record Number
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924097
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LA8pb2b2bz
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| Language of Document
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English
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| Main Entry
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Kantor, Robert; Kim, Ashley; Thyssen, Jacob; Silverberg, Jonathan I
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| Title & Author
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Association of atopic dermatitis with tobacco smoke exposure: a systematic review and meta- analysis [Article]\ Kantor, Robert; Kim, Ashley; Thyssen, Jacob; Silverberg, Jonathan I
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Dermatology Online Journal
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22/9
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| Date
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2016
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| Abstract
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Previous studies found conflicting results about whether exposure to tobacco smoke is associated with increased atopic dermatitis (AD). We examined this association by systematic review and meta-analysis of MEDLINE, EMBASE, Scopus, and Cochrane Library and identified 86 studies, including 680,176 patients from 39 countries. A meta-analysis was performed using random-effects models to estimate pooled odds ratios (OR). Subset analyses were performed for different ages (children or adult), regions, study designs (cross-sectional vs. longitudinal), sizes (<5,000 or ≥5,000) and quality (Newcastle-Ottawa Score [NOS] <6 or ≥6), and amount of smoking (mild or extensive). Overall, 17,969 (12.9% [range 1.2–50.0%]) were active smokers, 33,200 (15.3% [range 0.9–56.8%]) were passively exposed to tobacco smoke in the home and 14,004 (15.4% [range 2.3–34.4%]) of children born to mothers who smoked during pregnancy, respectively, had a previous and/or current history of AD. Atopic dermatitis was associated with higher odds of active smoking (random-effects OR [95% CI]: 1.87 [1.32–2.63]) and exposure to passive smoke (1.18 [1.01–1.38]), but not maternal smoking during pregnancy (1.06 [0.80–1.40]). In sensitivity analyses, the association between active smoking and AD remained significant in children and adults, in all continents studied and study sizes, but all studies were cross-sectional designs and had a NOS score ≥6. Exposure to passive smoke was associated with AD in children and adults, cross-sectional studies, South/Central American and African studies, study size <5,000 and NOS <6. This study demonstrates that active smoking and passive exposure to smoke are associated with increased AD prevalence.
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