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" Developmental origins of health and disease (DOHaD) : "
edited by Takeo Kubota, Hideoki Fukuoka.
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BL
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| Record Number
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889026
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| Title & Author
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Developmental origins of health and disease (DOHaD) : : from biological basis to clinical significance /\ edited by Takeo Kubota, Hideoki Fukuoka.
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| Publication Statement
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Singapore :: Springer,, [2018]
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, ©2018
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| Series Statement
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Advances in experimental medicine and biology,; volume 1012
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| Page. NO
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1 online resource (vii, 95 pages) :: illustrations (some color)
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| ISBN
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9789811055256
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: 9789811055263
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: 9811055254
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: 9811055262
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9789811055256
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| Bibliographies/Indexes
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Includes bibliographical references.
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| Contents
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Biological basis. One-carbon metabolism and lipid metabolism in DOHaD / Hideoki Fukuoka, Takeo Kubota -- Novel models of epigenetic gene regulation in the nutritional environment / Kazuki Mochizuki, Natsuyo Hariya, Takeo Kubota -- Epigenetic switching and neonatal nutritional environment / Koshi Hashimoto, Yoshihiro Ogawa -- Disease and environment. Developmental origins of nonalcoholic fatty liver disease (NAFLD) / Hiroaki Itoh, Naohiro Kanayama -- Fetal origins of hypertension / Yuichiro Arima, Koichi Nishiyama, Yasuhiro Izumiya, Koichi Kaikita, Seiji Hokimoto, Kenichi Tsujita -- Involvement of noncoding RNAs in stress-related neuropsychiatric diseases caused by DOHaD theory / Takahiro Nemoto, Yoshihiko Kakinuma -- Transgenerational mechanism and its consequences. Placental development and nutritional environment / Kosuke Taniguchi, Tomoko Kawai, Kenichiro Hata -- Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm / Ryuichi Kimura, Kaichi Yoshizaki, Noriko Osumi -- Clinical significance. Preemptive epigenetic medicine based on fetal programming / Takeo Kubota.
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| Abstract
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This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.
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| Subject
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Developmental biology.
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Diseases-- Causes and theories of causation.
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Developmental biology.
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Diseases-- Causes and theories of causation.
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HEALTH FITNESS-- Diseases-- General.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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Disease-- etiology.
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Prenatal Exposure Delayed Effects.
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Developmental Biology.
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Disease Susceptibility.
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Embryology.
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Developmental Biology.
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| Dewey Classification
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616.07/1
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| LC Classification
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RB152
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| NLM classification
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QZ 40
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| Added Entry
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Fukuoka, Hideoki
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Kubota, Takeo
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