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" Total synthesis of natural products with antimicrobial activity / "
Andrew Giltrap.
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BL
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| Record Number
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889415
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| Main Entry
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Giltrap, Andrew
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| Title & Author
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Total synthesis of natural products with antimicrobial activity /\ Andrew Giltrap.
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| Publication Statement
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Singapore :: Springer,, 2018.
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| Series Statement
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Springer theses,
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| Page. NO
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1 online resource (xxiv, 268 pages) :: illustrations (some color)
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| ISBN
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9789811088063
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: 9811088063
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9789811088056
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9811088055
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| Contents
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Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental.
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| Abstract
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This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
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Anti-infective agents.
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Clinical biochemistry.
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Natural products.
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Pharmaceutical chemistry.
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Anti-infective agents.
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Clinical biochemistry.
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MEDICAL-- Pharmacology.
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Natural products.
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Pharmaceutical chemistry.
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Chemistry.
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Drug Resistance.
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Medical Biochemistry.
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Medicinal Chemistry.
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| Dewey Classification
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615.7/92
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| LC Classification
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QD375
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