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" Development of antibody-based therapeutics : "
Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors.
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BL
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| Record Number
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889633
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| Title & Author
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Development of antibody-based therapeutics : : translational considerations challenges /\ Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors.
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| Edition Statement
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Second edition.
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| Publication Statement
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Singapore :: Adis,, [2018]
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| Page. NO
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1 online resource
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| ISBN
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9789811304965
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: 9811304963
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9789811304958
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9811304955
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| Bibliographies/Indexes
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Includes bibliographical references.
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| Contents
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Introduction -- Translational considerations and challenges : an overview -- Considerations for construct and affinity design goals -- Epitope characterization and isotype selection -- Biophysical considerations for development of antibody-based therapeutics -- Novel technologies for generation of bispecific constructs -- Stimulus-response mechanisms : an overview -- Evaluation of tumor growth inhibition in preclinical tumor models : a quantitative approach -- Application of proof-of-mechanism biomarkers (POM) in design and development of biologics modalities -- Antibody drug conjugates : translational considerations -- Application of PK-PD modeling and simulation approaches for immuno-oncology drugs -- Translational biomarkers : application in the clinical development of combination therapies -- Correction to : considerations for construct and affinity design goals.
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| Abstract
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This book examines vital considerations in designing effective translational strategies in the development of antibody-based therapeutics, including the relationship between the 'unit dose' and 'unit effect' with respect to beneficial and deleterious effects.
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| Subject
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Monoclonal antibodies-- Therapeutic use.
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Biochemistry.
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MEDICAL-- Pharmacology.
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Monoclonal antibodies-- Therapeutic use.
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Pharmacology.
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Pharmacy-- dispensing.
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Antibodies, Monoclonal-- pharmacology.
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Antibodies, Monoclonal-- therapeutic use.
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Antigens-- immunology.
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Drug Discovery.
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Translational Medical Research.
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| Dewey Classification
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615.37
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| LC Classification
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RM282.M65D48 2018
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| Added Entry
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Bornstein, Gadi G.
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Klakamp, Scott L.
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Tabrizi, Mohammad A.
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