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" Chromosome translocation / "
Yu Zhang, editor.
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BL
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| Record Number
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889662
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| Title & Author
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Chromosome translocation /\ Yu Zhang, editor.
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| Publication Statement
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Singapore :: Springer,, [2018]
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, ©2018
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| Series Statement
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Advances in experimental medicine and biology,; volume 1044
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| Page. NO
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1 online resource (v, 168 pages) :: illustrations (some color)
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| ISBN
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9789811305931
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: 9811305935
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9789811305924
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9811305927
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| Bibliographies/Indexes
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Includes bibliographical references.
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| Contents
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Historical and clinical perspectives on chromosomal translocations / Ellen S. Wilch, Cynthia C. Morton -- Induction of chromosomal translocations with CRISPR-Cas9 and other nucleases: understanding the repair mechanisms that give rise to translocations / Erika Brunet, Maria Jasin -- Dynamics of double-strand breaks: implications for the formation of chromosome translocations / Henrike Johanna Gothe, Vera Minneker, Vassilis Roukos -- The CRISPR/Cas9 system as a tool to engineer chromosomal translocation in vivo / Taek-Chin Cheong, Rafael B. Blasco, Roberto Chiarle -- Generation of genomic alteration from cytidine deamination / Xiaojing Liu, Fei-Long Meng -- The role for the DSB response pathway in regulating chromosome translocations / Rajib Ghosh, Debamitra Das, Sonia Franco -- Telomeres and chromosomal translocations / Duncan M. Baird, Eric A. Hendrickson -- 3D genome organization influences the chromosome translocation pattern / Rachel Patton McCord, Adayabalam Balajee -- The role of chromosome deletions in human cancers / Mei Chen, Yi Yang, Yu Liu, Chong Chen -- Processing-challenges generated by clusters of DNA double-strand breaks underpin increased effectiveness of high-LET radiation and chromothripsis / Emil Mladenov, Janapriya Saha, George Iliakis.
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| Abstract
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"This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases. The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation"--Publisher's description.
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| Subject
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Translocation (Genetics)
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SCIENCE-- Life Sciences-- Biochemistry.
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Translocation (Genetics)
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Translocation, Genetic-- physiology.
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| Dewey Classification
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572.8/77
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| LC Classification
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QH462.T7
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| NLM classification
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QU 477
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| Added Entry
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Zhang, Yu
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