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BL
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| Record Number
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889805
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| Title & Author
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Applied computational genomics /\ Yin Yao, editor.
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| Edition Statement
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Second edition.
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| Publication Statement
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Singapore :: Springer,, 2018.
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| Series Statement
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Translational bioinformatics,; volume 13
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| Page. NO
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1 online resource
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| ISBN
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9789811310706
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: 9789811310713
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: 9789811310720
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: 9789811345616
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: 981131070X
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: 9811310718
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: 9811310726
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: 9811345619
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9789811310706
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| Contents
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Intro; Contents; Contributors; Chapter 1: Introduction; 1.1 Overview; 1.2 Overview ofChapter Contents; References; Chapter 2: Exploring Polygenic Overlap Between ADHD andOCD; 2.1 Introduction; 2.2 Polygenic Risk Score Analyses; 2.3 Protein-Protein Link Evaluation; 2.4 Expression Quantitative Trait Locus (eQTL) Analysis; 2.5 Meta-analysis; 2.6 Discussion; References; Web Resources; Chapter 3: Concepts ofGenetic Epidemiology; 3.1 Introduction: Genetic Epidemiology; 3.1.1 Family Studies; 3.1.2 Twin Studies; 3.1.3 Adoption Studies; 3.1.4 Migration Studies.
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3.2 Applications ofGenetic Epidemiology toGene Identification3.2.1 Samples; 3.2.2 Selection ofControls; 3.2.3 Risk Estimation; 3.2.4 Identification ofEnvironmental Factors; 3.3 Applications, Impact, andFuture Directions; References; Chapter 4: Rare Variant Analysis inUnrelated Individuals; 4.1 Introduction; 4.1.1 Success ofGWAS andIts Limitation; 4.1.2 Detecting Rare Variants; 4.2 Data Description andMethods; 4.2.1 Data Describe; 4.2.2 Methods; 4.2.2.1 Collapsing Method; 4.2.2.2 Combined Multivariate andCollapsing; 4.2.2.3 Weighted Sum Association Method (WSM).
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4.2.2.4 Pooled Association Tests forRare Variants4.2.2.5 A Data-Adaptive Sum Test (Consider theDirection); 4.2.2.6 Alpha Test; 4.2.2.7 Sequence Kernel Association Test (SKAT); 4.2.2.8 A General Framework forDetecting Disease Associations withRare Variants inSequencing Studies; 4.2.2.9 Haplotype-Based Collapsing Test; 4.2.2.10 Odds Ratio Weighted Sum Statistic (ORWSS); 4.2.2.11 Combining Related andUnrelated Individual Together toDetect Rare Variants; 4.3 Discussion; References; Chapter 5: Whole-Genome Association Analysis of Treatment Response from Obsessive-Compulsive Disorder.
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5.1 Introduction5.2 Material andMethods; 5.3 Statistical Methods; 5.4 Results; 5.5 Discussion; References; Chapter 6: QTL Mapping ofMolecular Traits forStudies ofHuman Complex Diseases; 6.1 Introduction; 6.1.1 Genome-Wide Association Study andIts Limitation; 6.1.2 Functionality ofGenetic Variants; 6.1.3 QTL Mapping andGenetic Variants; 6.2 QTL Mapping ofMolecular Traits; 6.2.1 eQTL; 6.2.1.1 Experimental Platforms; 6.2.1.2 RNA Quality; 6.2.1.3 Sample Heterogeneity; 6.2.1.4 Sample Size; 6.2.1.5 Covariates; 6.2.1.6 Analytical Procedures; 6.2.1.7 Significance Criteria; 6.2.2 mQTL.
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6.3 Other Types ofQuantitative Traits6.4 Software andAlgorithm forQTL Mapping; 6.5 Applications ofQTL Mapping inGenetic Studies ofComplex Diseases; 6.6 Database or QTL Mapping Results; References; Chapter 7: From Family Study to Population Study: A History of Genetic Mapping for Nasopharyngeal Carcinoma (NPC); 7.1 Introduction; 7.2 The Working Model; 7.3 Candidate-Gene Association Studies; 7.3.1 Apoptosis andCell Cycle Arrest Pathways; 7.3.2 Carcinogen Metabolism andDetoxification Pathways; 7.3.3 DNA Repair Pathways; 7.3.4 Cytokines andGrowth Factors; 7.3.5 Cell Adhesion.
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| Abstract
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The volume provides a review of statistical development and application in the area of human genomics, including candidate gene mapping, linkage analysis, population-based genome-wide association, exon sequencing, and whole genome sequencing analysis. The authors are extremely experienced in the field of statistical genomics and will give a detailed introduction to the evolution of the field, as well as critical comments on the advantages and disadvantages of the proposed statistical models. The future directions of translational biology will also be described.
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| Subject
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Bioinformatics.
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| Subject
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Genomics-- Mathematics.
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Bioinformatics.
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Biotechnology.
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Medical genetics.
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Molecular biology.
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SCIENCE-- Life Sciences-- Biochemistry.
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| Dewey Classification
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572.8/6
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| LC Classification
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QH447
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| Added Entry
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Yao, Yin
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