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BL
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| Record Number
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889904
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| Title & Author
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Heart genomics /\ Hong Jiang, Ming Liu, editors.
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| Publication Statement
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Singapore :: Springer,, 2018.
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| Series Statement
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Translational bioinformatics ;; v. 16
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| Page. NO
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1 online resource
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| ISBN
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9789811314292
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: 9789811314308
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: 9811314292
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: 9811314306
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9789811314285
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9811314284
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| Bibliographies/Indexes
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Includes bibliographical references.
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| Contents
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Intro; Contents; Chapter 1: Genome-Wide Association Studies ofHypertension andSeveral Other Cardiovascular Diseases; 1 Introduction; 2 GWAS Significant Loci; 2.1 Blood Pressure; 2.2 Coronary Artery Disease (CAD); 3 Clinical Implications; 3.1 Hypertension; 3.2 CAD; 4 Perspectives; References; Chapter 2: Cardiac Transcriptome Profile inHeart Diseases; 1 Introduction; 2 Technology Platforms; 2.1 Methods forCardiac Transcriptome; 2.1.1 RNA Sequencing; 2.1.2 Microarray Analysis; 2.1.3 Array RT-qPCR; 2.1.4 Evaluation andComparison; 2.2 Analysis ofTranscriptome Data
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2.2 Histone Modification withCVDs2.2.1 Histone Modification withHypoxia andShear Stress; 2.2.2 Histone Modifications withCAD; 2.2.3 Histone Modifications andHF; 2.2.4 Histone Modifications withHypertension andPulmonary Arterial Hypertension (PAH); 2.3 RNA Silencing withCVDs; 2.3.1 miRNAs andCardiac Aging; 2.3.2 miRNAs andHF; 2.3.3 miRNAs asPotential Biomarkers; 3 The Environment, Epigenetics, andCVD Risk; 3.1 Natural Environmental Exposures; 3.2 Personal Environment; 4 Technical Overview ofPlatform Used inEpigenetic Study
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2.2.1 De Novo Transcriptome Analysis2.2.2 Transcriptome Analysis withReference Genome; 2.3 Intact Hearts vs. Isolated Cells inCardiac Disease Studies; 3 Developmental Transcriptome Profiles ofCardiac Cells; 3.1 Developmental Transcriptional Profiles ofCardiomyocytes; 3.1.1 The Developmental Spatial Transcriptomes ofCMs; 3.1.2 The Developmental Temporal Transcriptomes ofCMs; 3.1.3 The Noncoding RNAs inCMs; 3.2 Developmental Transcriptional Profiles ofEndothelial Cells; 3.2.1 The Developmental Temporal Transcriptomes ofECs; 3.2.2 The Function-Related Gene Expression inECs
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3.2.3 Gene Expression inECs that Participate inthePathogenesis ofAtherosclerosis3.2.4 The Noncoding RNAs inECs; 3.3 Developmental Transcriptional Profiles ofFibroblasts; 3.3.1 The Function-Related Gene Expression inCFs; 3.3.2 The Noncoding RNAs inCFs; 4 Transcriptomics-Based Biomarkers inTypical Heart Disease; 4.1 Coronary Artery Disease (CAD); 4.1.1 Traditional Biomarkers ofMI; 4.1.2 Message RNAs Implicated inthePrediction andDetection ofMI; 4.1.3 MiRNAs andLncRNAs asDiagnostic Tools inCAD; 4.2 Congestive Heart Failure; 4.2.1 Blood-Based Biomarkers inCHF
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4.2.2 Expression Profiling ofHuman Cardiac Tissues inCHF4.2.3 CHF Related Noncoding RNAs; 4.3 Congenital Heart Disease; 4.3.1 Expression Profiling ofCHD; 4.3.2 MicroRNAs inCHD; References; Chapter 3: The Emerging Role ofEpigenetics; 1 Introduction; 1.1 Cardiovascular Diseases; 1.2 Epigenetics; 1.3 DNA Methylation; 1.4 Histone Modifications; 1.5 Noncoding RNAs; 2 Epigenetics andDiseases; 2.1 DNA Methylation andDiseases; 2.1.1 DNA Methylation andCancer; 2.1.2 DNA Methylation andAtherosclerosis; 2.1.3 DNA Methylation withCardiovascular Risk andDiseases
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| Abstract
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This book elucidates how advances in genomics research are being applied in connection with heart diseases. It describes the development of genome-scale technologies and their applications to all areas of cardiac investigations, such as genomics, functional genomics, epigenomics, etc., and how they relate to a series of important breakthroughs in various heart diseases. Applying unbiased genomics, combined with a disease-focused and hypothesis-driven approach, represents a promising way to advance our understanding of cardiac diseases. The book offers an important reference work on introducing genomics in heart disease for all scientists and graduate students whose work involves genomics and cardiology, as well as for clinical physicians.
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| Subject
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Genomics-- Research.
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Heart-- Diseases-- Genetic aspects.
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Medical genetics.
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Cardiovascular medicine.
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HEALTH FITNESS-- Diseases-- General.
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Heart-- Diseases-- Genetic aspects.
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Medical genetics.
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Medical genetics.
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Medical research.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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| Dewey Classification
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616.1/2
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| LC Classification
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RC682
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| Added Entry
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Jiang, Hong
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Liu, Ming
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