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" Antibody Genetics "


Document Type : Latin Dissertation
Language of Document : English
Record Number : 897199
Doc. No : TL9bp9b31b
Main Entry : Bayog, Maria Lourdes Geronimo
Title & Author : Antibody Genetics\ Cole, Charles KennethVollmers, Christopher
Date : 2019
student score : 2019
Abstract : Antibodies are created through a unique mechanism whereby different gene segments at the antibody loci are semi-randomly recombined to form functional antibody genes. This process allows that adaptive immune system to generate protection against a near-infinite array of pathogens, however it presents unique challenges from a sequencing prospective. I present three projects addressing problems facing the repertoire sequencing community including a method for full-length antibody transcript sequencing, a method for heavy and light chain pairing in single B cells, and a method for generating repertoires as a byproduct of a general polyA RNA sequencing protocol.
Added Entry : Cole, Charles Kenneth
Added Entry : UC Santa Cruz
copyhttps://lib.clisel.com/site/catalogue/897199
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