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" The Menopausal-related Symptom Experience In Women With Breast Cancer "
Mazor, Melissa Beth
Miaskowski, Christine
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Latin Dissertation
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English
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| Record Number
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897943
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TL5cw048s5
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| Main Entry
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Jackson, Shantina Shannell
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| Title & Author
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The Menopausal-related Symptom Experience In Women With Breast Cancer\ Mazor, Melissa BethMiaskowski, Christine
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| Date
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2017
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2017
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| Abstract
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Prior to and following breast cancer treatment women experience multiple co-occurring menopausal-related symptoms. The purposes of this dissertation research were: to evaluate for the differences in multiple dimensions of menopausal-related symptoms between pre- and postmenopausal women prior to and at 12 months following breast cancer surgery; to evaluate for differences in the number and types of menopausal-related symptom clusters at both time points using ratings of occurrence and severity; and to evaluate for changes in these symptom clusters over time. Menopausal-related symptoms were evaluated using the Menopausal Symptoms Scale (MSS). Of the 312 women enrolled prior to surgery, 37.4% were premenopausal and 62.6% were postmenopausal. In the multivariate analysis, premenopausal patients reported higher occurrence rates for urinary frequency (p=.006) and reported lower occurrence rates for joint pain/stiffness (p=.011), difficulty falling asleep (p=.025), and vaginal dryness (p=.002). A significant interaction was found between age and menopausal status for hot flashes (p=.002), wake during the night (p=.025), and headache (.040). Of the 327 women with breast cancer who completed the 12-month assessment, 35.2% were premenopausal and 64.8% were postmenopausal prior to surgery. In the conditional models that evaluated seven symptoms (i.e., hot flashes, night sweats, depression, daytime sweats, joint pain or stiffness, wake during the night, numbness or tingling), for which significant interactions were found between age and menopausal status, the differences in symptom occurrence rates between pre- and postmenopausal patients depended on their age. Of the 398 women evaluated for symptom clusters, the mean number of symptoms was 13.2 ± 8.5 at enrollment and 10.9 ± 8.2 at 12 months after surgery. Using exploratory factor analysis, eight distinct symptom clusters were identified prior to and at 12 months following surgery using occurrence and severity. Only two symptom clusters (i.e., pain/discomfort and hormonal) were relatively stable across both dimensions and time points and two symptom clusters were relatively stable across both dimensions either prior to surgery (i.e., sleep/psychological/cognitive) or at 12 months after surgery (i.e., sleep). The other four clusters (i.e., irritability, psychological/cognitive, cognitive, psychological) were identified at one time point using a single dimension.
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Mazor, Melissa Beth
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UCSF
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