Agent-Based Modeling in Molecular Systems Biology.

منو

" Agent-Based Modeling in Molecular Systems Biology. "
Soheilypour, MohammadMofrad, Mohammad RK

Document Type	:	AL
Record Number	:	901119
Doc. No	:	LA8jr5j73x
Title & Author	:	Agent-Based Modeling in Molecular Systems Biology. [Article]\ Soheilypour, MohammadMofrad, Mohammad RK
Date	:	2018
Title of Periodical	:	UC Berkeley
Abstract	:	Molecular systems orchestrating the biology of the cell typically involve a complex web of interactions among various components and span a vast range of spatial and temporal scales. Computational methods have advanced our understanding of the behavior of molecular systems by enabling us to test assumptions and hypotheses, explore the effect of different parameters on the outcome, and eventually guide experiments. While several different mathematical and computational methods are developed to study molecular systems at different spatiotemporal scales, there is still a need for methods that bridge the gap between spatially-detailed and computationally-efficient approaches. In this review, we summarize the capabilities of agent-based modeling (ABM) as an emerging molecular systems biology technique that provides researchers with a new tool in exploring the dynamics of molecular systems/pathways in health and disease.