Single-cell analysis tools for drug discovery and development.

منو

" Single-cell analysis tools for drug discovery and development. "
Heath, James RRibas, AntoniMischel, Paul S

Document Type	:	AL
Record Number	:	902180
Doc. No	:	LA8794p3w7
Title & Author	:	Single-cell analysis tools for drug discovery and development. [Article]\ Heath, James RRibas, AntoniMischel, Paul S
Date	:	2016
Title of Periodical	:	UCLA
Abstract	:	The genetic, functional or compositional heterogeneity of healthy and diseased tissues presents major challenges in drug discovery and development. Such heterogeneity hinders the design of accurate disease models and can confound the interpretation of biomarker levels and of patient responses to specific therapies. The complex nature of virtually all tissues has motivated the development of tools for single-cell genomic, transcriptomic and multiplex proteomic analyses. Here, we review these tools and assess their advantages and limitations. Emerging applications of single cell analysis tools in drug discovery and development, particularly in the field of oncology, are discussed.