A case of wolfram syndrome.

منو

" A case of wolfram syndrome. "
Naderian, Gholamali; Ashtari, Fereshteh; Nouri-Mahdavi, Kia; Sajjadi, Valleh

Document Type	:	AL
Record Number	:	910252
Doc. No	:	LA7r57f3cp
Title & Author	:	A case of wolfram syndrome. [Article]\ Naderian, Gholamali; Ashtari, Fereshteh; Nouri-Mahdavi, Kia; Sajjadi, Valleh
Date	:	2010
Title of Periodical	:	UCLA
Abstract	:	PURPOSE:To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. CASE REPORT:A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of -0.25+1.50@55 and -0.25+1.50@131 in his right and left eyes, respectively. Bilateral optic atrophy was evident on fundus examination. The patient also had diabetes insipidus, neurosensory deafness, neurogenic bladder, polyuria and extra-residual voiding indicating atony of the urinary tract, combined with delayed sexual maturity. CONCLUSION:One should consider Wolfram syndrome in patients with juvenile onset diabetes mellitus and hearing loss. Ophthalmological examination may disclose optic atrophy; urologic examinations are vital in such patients.