In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spa...

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" In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy. "
Saager, Rolf B; Sharif, Ata; Kelly, Kristen M; Durkin, Anthony J

Document Type	:	AL
Record Number	:	911543
Doc. No	:	LA6203n73j
Title & Author	:	In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy. [Article]\ Saager, Rolf B; Sharif, Ata; Kelly, Kristen M; Durkin, Anthony J
Date	:	2016
Title of Periodical	:	UC Irvine
Abstract	:	Skin is a highly structured tissue, raising concerns as to whether skin pigmentation due to epidermal melanin may confound accurate measurements of underlying hemodynamics. Using both venous and arterial cuff occlusions as a means of inducing differential hemodynamic perturbations, we present analyses of spectra limited to the visible or near-infrared regime, in addition to a layered model approach. The influence of melanin, spanning Fitzpatrick skin types I to V, on underlying estimations of hemodynamics in skin as interpreted by these spectral regions are assessed. The layered model provides minimal cross-talk between melanin and hemodynamics and enables removal of problematic correlations between measured tissue oxygenation estimates and skin phototype.