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" Feasibility of combination allogeneic stem cell therapy for spinal cord injury: "
Ichim, Thomas E; Solano, Fabio; Lara, Fabian; Paris, Eugenia; Ugalde, Federico; Rodriguez, Jorge; Minev, Boris; Bogin, Vladimir; Ramos, Famela; Woods, Erik J; Murphy, Michael P; Patel, Amit N; Harman, Robert J; Riordan, Neil H
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AL
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| Record Number
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911730
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LA23x1k44q
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| Title & Author
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Feasibility of combination allogeneic stem cell therapy for spinal cord injury:. a case report [Article]\ Ichim, Thomas E; Solano, Fabio; Lara, Fabian; Paris, Eugenia; Ugalde, Federico; Rodriguez, Jorge; Minev, Boris; Bogin, Vladimir; Ramos, Famela; Woods, Erik J; Murphy, Michael P; Patel, Amit N; Harman, Robert J; Riordan, Neil H
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2010
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| Title of Periodical
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UC San Diego
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| Abstract
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Abstract Cellular therapy for spinal cord injury (SCI) is overviewed focusing on bone marrow mononuclear cells, olfactory ensheathing cells, and mesenchymal stem cells. A case is made for the possibility of combining cell types, as well as for allogeneic use. We report the case of 29 year old male who suffered a crush fracture of the L1 vertebral body, lacking lower sensorimotor function, being a score A on the ASIA scale. Stem cell therapy comprised of intrathecal administration of allogeneic umbilical cord blood ex-vivo expanded CD34 and umbilical cord matrix MSC was performed 5 months, 8 months, and 14 months after injury. Cell administration was well tolerated with no adverse effects observed. Neuropathic pain subsided from intermittent 10/10 to once a week 3/10 VAS. Recovery of muscle, bowel and sexual function was noted, along with a decrease in ASIA score to "D". This case supports further investigation into allogeneic-based stem cell therapies for SCI.
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