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" Mutation Rate Switch inside Eurasian Mitochondrial Haplogroups: "
Pierron, Denis; Chang, Ivan; Arachiche, Amal; Heiske, Margit; Thomas, Olivier; Borlin, Marine; Pennarun, Erwan; Murail, Pacal; Thoraval, Didier; Rocher, Christophe; Letellier, Thierry
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AL
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| Record Number
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912509
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| Doc. No
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LA81j1n320
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| Title & Author
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Mutation Rate Switch inside Eurasian Mitochondrial Haplogroups:. Impact of Selection and Consequences for Dating Settlement in Europe [Article]\ Pierron, Denis; Chang, Ivan; Arachiche, Amal; Heiske, Margit; Thomas, Olivier; Borlin, Marine; Pennarun, Erwan; Murail, Pacal; Thoraval, Didier; Rocher, Christophe; Letellier, Thierry
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2011
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| Title of Periodical
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UC Irvine
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| Abstract
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R-lineage mitochondrial DNA represents over 90% of the European population and is significantly present all around the planet (North Africa, Asia, Oceania, and America). This lineage played a major role in migration “out of Africa” and colonization in Europe. In order to determine an accurate dating of the R lineage and its sublineages, we analyzed 1173 individuals and complete mtDNA sequences from Mitomap. This analysis revealed a new coalescence age for R at 54.500 years, as well as several limitations of standard dating methods, likely to lead to false interpretations. These findings highlight the association of a striking under-accumulation of synonymous mutations, an over-accumulation of non-synonymous mutations, and the phenotypic effect on haplogroup J. Consequently, haplogroup J is apparently not a Neolithic group but an older haplogroup (Paleolithic) that was subjected to an underestimated selective force. These findings also indicated an under-accumulation of synonymous and non-synonymous mutations localized on coding and non-coding (HVS1) sequences for haplogroup R0, which contains the major haplogroups H and V. These new dates are likely to impact the present colonization model for Europe and confirm the late glacial resettlement scenario.
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