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" European population substructure: "
Seldin, Michael; Shigeta, Russell; Villoslada, Pablo; Selmi, Carlo; Tuomilehto, Jaakko; Silva, Gabriel; Belmont, John; Klareskog, Lars; Gregersen, Peter
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AL
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| Record Number
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912944
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LA6b33j90g
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| Title & Author
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European population substructure:. clustering of northern and southern populations. [Article]\ Seldin, Michael; Shigeta, Russell; Villoslada, Pablo; Selmi, Carlo; Tuomilehto, Jaakko; Silva, Gabriel; Belmont, John; Klareskog, Lars; Gregersen, Peter
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2006
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UC Davis
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| Abstract
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Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans. Under a variety of conditions and tests, there is a consistent and reproducible distinction between northern and southern European population groups: most individual participants with southern European ancestry (Italian, Spanish, Portuguese, and Greek) have >85% membership in the southern population; and most northern, western, eastern, and central Europeans have >90% in the northern population group. Ashkenazi Jewish as well as Sephardic Jewish origin also showed >85% membership in the southern population, consistent with a later Mediterranean origin of these ethnic groups. Based on this work, we have developed a core set of informative SNP markers that can control for this partition in European population structure in a variety of clinical and genetic studies.
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