Analysis of the genetic basis of height in large Jewish nuclear families.

مرکز و کتابخانه مطالعات اسلامی به زبان های اروپایی

منو

" Analysis of the genetic basis of height in large Jewish nuclear families. "
Zeevi, Danny; Bloom, Joshua S; Sadhu, Meru J; Ben Yehuda, Adi; Zangen, David; Levy-Lahad, Ephrat

Document Type	:	AL
Record Number	:	920540
Doc. No	:	LA9px8g3xm
Title & Author	:	Analysis of the genetic basis of height in large Jewish nuclear families. [Article]\ Zeevi, Danny; Bloom, Joshua S; Sadhu, Meru J; Ben Yehuda, Adi; Zangen, David; Levy-Lahad, Ephrat
Date	:	2019
Title of Periodical	:	Lawrence Berkeley National Laboratory
Abstract	:	Despite intensive study, most of the specific genetic factors that contribute to variation in human height remain undiscovered. We conducted a family-based linkage study of height in a unique cohort of very large nuclear families from a founder (Jewish) population. This design allowed for increased power to detect linkage, compared to previous family-based studies. Loci we identified in discovery families could explain an estimated lower bound of 6% of the variance in height in validation families. We showed that these loci are not tagging known common variants associated with height. Rather, we suggest that the observed signals arise from variants with large effects that are rare globally but elevated in frequency in the Jewish population.