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" Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (DLBCL) in a patient taking fingolimod "
Wills, Abby; Fan, Guang; Kim, Edward; Okada, Craig Y; White, Kevin P; Hopkins, R Samuel
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AL
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| Record Number
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921758
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LA2g62q2fq
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| Language of Document
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English
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| Main Entry
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Wills, Abby; Fan, Guang; Kim, Edward; Okada, Craig Y; White, Kevin P; Hopkins, R Samuel
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| Title & Author
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Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (DLBCL) in a patient taking fingolimod [Article]\ Wills, Abby; Fan, Guang; Kim, Edward; Okada, Craig Y; White, Kevin P; Hopkins, R Samuel
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| Title of Periodical
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Dermatology Online Journal
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25/9
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| Date
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2019
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| Abstract
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A 55-year-old man with relapsing-remitting multiple sclerosis on fingolimod presented to the dermatology clinic with skin lesions on the left temple and cheek. Histopathology showed a diffuse infiltrate of enlarged, atypical lymphocytes throughout the dermis with an overlying grenz zone and a subpopulation of scattered smaller lymphocytes and plasma cells. Epstein-Barr virus-encoded RNA in situ hybridization stain was positive. Based on the morphologic and immunophenotypic findings, a diagnosis of EBV-positive diffuse large B-cell lymphoma was made. This case aims to raise awareness for the dermatologist that patients on fingolimod may be at increased risk of lymphoproliferative disorders.
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