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" Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease "
Sun, Christina W; Grossman, Shoshana K; Valdes-Rodriguez, Rodrigo; Lee, Jason B; Hsu, Sylvia
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AL
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| Record Number
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923114
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LA5938q4rj
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| Language of Document
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English
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| Main Entry
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Sun, Christina W; Grossman, Shoshana K; Valdes-Rodriguez, Rodrigo; Lee, Jason B; Hsu, Sylvia
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| Title & Author
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Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease [Article]\ Sun, Christina W; Grossman, Shoshana K; Valdes-Rodriguez, Rodrigo; Lee, Jason B; Hsu, Sylvia
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| Title of Periodical
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Dermatology Online Journal
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26/1
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| Date
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2020
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| Abstract
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A distinct Darier phenotype presenting with confetti-like hypopigmented macules was first described in 1965. Designated as ''guttate leukoderma,'' this skin finding is a rarely-reported presentation of Darier disease. It has been theorized that the mutation in ATP2A2 causes defective E-cadherin, which in turn disrupts the adhesion of melanocytes to keratinocytes, thus leading to impaired dendrite formation, hindered melanin transfer, and ultimately to melanocyte apoptosis. Herein, we contribute a case of a 56-year old woman who presented with the rarely-described guttate leukoderma of Darier disease and acrokeratosis verruciformis of Hopf.
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