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" A review of intralesional wart therapy "
Muse, Mikél E; Stiff, Katherine M; Glines, Katelyn R; Cline, Abigail; Feldman, Steven R
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AL
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| Record Number
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923146
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LA3md9z8gj
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| Language of Document
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English
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| Main Entry
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Muse, Mikél E; Stiff, Katherine M; Glines, Katelyn R; Cline, Abigail; Feldman, Steven R
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| Title & Author
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A review of intralesional wart therapy [Article]\ Muse, Mikél E; Stiff, Katherine M; Glines, Katelyn R; Cline, Abigail; Feldman, Steven R
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| Title of Periodical
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Dermatology Online Journal
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26/3
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| Date
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2020
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| Abstract
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Background: New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and candida antigen but there have been limited studies to compare their efficacies. Objective: The purpose of this systematic review is to compare the efficacy and safety of injectable agents used for the treatment of warts.Methods: A PubMed search included terms “intralesional wart therapy,” “wart injection” and “verruca injection.” Articles reviewed were published over 10 years.Results: A total of 43 articles were reviewed; 30 covered studies with more than 10 participants and 13 were case reports, case series, and reviews. In comparison studies intralesional agents have equal or superior efficacy (66%-94.9%) compared to first-line salicylic acid or cryotherapy (65.5-76.5%). One advantage of intralesional injections is the rate of complete resolution of distant warts.Limitations: Each study varied in their agents, treatment interval, and treatment dose, making comparisons difficult.Conclusions: Intralesional wart injections are safe, affordable, and efficacious treatments for warts. Physicians should consider intralesional injections for patients with refractory warts, multiple warts, or warts in sensitive areas.
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