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" Regression of cutaneous invasive squamous cell carcinoma in a patient with chronic cutaneous graft versus host disease "
Balagula, Yevgeniy; Taube, Janis M; Wang, Timothy; Dorafshar, Amir H; Sweren, Ronald J
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AL
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| Record Number
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923685
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LA3zr67781
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| Language of Document
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English
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| Main Entry
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Balagula, Yevgeniy; Taube, Janis M; Wang, Timothy; Dorafshar, Amir H; Sweren, Ronald J
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| Title & Author
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Regression of cutaneous invasive squamous cell carcinoma in a patient with chronic cutaneous graft versus host disease [Article]\ Balagula, Yevgeniy; Taube, Janis M; Wang, Timothy; Dorafshar, Amir H; Sweren, Ronald J
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| Title of Periodical
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Dermatology Online Journal
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| Volume/ Issue Number
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20/5
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| Date
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2014
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| Abstract
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Numerous complications can be observed in the post-transplant period among recipients of hematopoietic stem cells including graft-versus-host disease (GVHD), which is associated with significant morbidity and mortality. On the other hand, graft versus tumor (GVT) effect is a well-described phenomenon in patients with hematologic malignancies and has also been reported in renal cell cancer, ovarian cancer, breast carcinoma, and melanoma. We describe spontaneous regression of a cutaneous invasive squamous cell carcinoma and multifocal atypical intraepidermal proliferations in a patient with chronic graft-versus-host disease following initiation of extracorporeal photopheresis (ECP). This observation raises questions regarding the GVT in cutaneous neoplasms and potential immunomodulatory effects of ECP.
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