Multiple labial melanotic macules occurring after topical application of calcineurin inhibitors

منو

" Multiple labial melanotic macules occurring after topical application of calcineurin inhibitors "
Shi, Vivian Y; Joo, Jayne S; Sharon, Victoria R

Document Type	:	AL
Record Number	:	923741
Doc. No	:	LA45k792vj
Language of Document	:	English
Main Entry	:	Shi, Vivian Y; Joo, Jayne S; Sharon, Victoria R
Title & Author	:	Multiple labial melanotic macules occurring after topical application of calcineurin inhibitors [Article]\ Shi, Vivian Y; Joo, Jayne S; Sharon, Victoria R
Title of Periodical	:	Dermatology Online Journal
Volume/ Issue Number	:	20/8
Date	:	2014
Abstract	:	Topical calcineurin inhibitors are widely used to treat inflammatory dermatoses for their steroid-sparing advantage. Herein, we report a patient with chronic lip dermatitis who developed multiple labial melanotic macules after application of tacrolimus 0.1% ointment and pimecrolimus 1% cream. Prior and current reports raise concerns for potential development of pigmented lesions associated with topical calcineurin inhibitor use. These reports highlight the need for careful risk-benefit assessment when prescribing topical calcineurin inhibitors for inflammatory dermatoses, especially when used on sun-exposed sites.