Zebrafish for modeling skin disorders

منو

" Zebrafish for modeling skin disorders "
Cline, Abigail; Feldman, Steven R

Document Type	:	AL
Record Number	:	924073
Doc. No	:	LA4ws351w8
Language of Document	:	English
Main Entry	:	Cline, Abigail; Feldman, Steven R
Title & Author	:	Zebrafish for modeling skin disorders [Article]\ Cline, Abigail; Feldman, Steven R
Title of Periodical	:	Dermatology Online Journal
Volume/ Issue Number	:	22/8
Date	:	2016
Abstract	:	The experimental advantages of zebrafish make this model system highly amenable to the field of dermatology. Zebrafish skin development is similar to humans and its genome is ~70% orthologous to the human genome. Its external developmental process allows for genetic manipulation and analysis of embryogenesis within a short time frame with all important internal organs and skin compartments formed within 6 days. Zebrafish models of cutaneous human diseases offer insight into pathogenesis and a unique platform for testing of potential therapies. This review details the specific advantages of zebrafish and highlights its use in dermatological research.