Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the US

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" Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the US "
Hsu, Derek Y

Document Type	:	AL
Record Number	:	924125
Doc. No	:	LA7tm9h8kp
Language of Document	:	English
Main Entry	:	Hsu, Derek Y
Title & Author	:	Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the US [Article]\ Hsu, Derek Y
Title of Periodical	:	Dermatology Online Journal
Volume/ Issue Number	:	22/9
Date	:	2016
Abstract	:	Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening blistering disorders. Few studies have addressed SJS/TEN in children. We sought to determine risk factors, comorbidities, inpatient burden and mortality in US children with SJS, SJS-TEN and TEN. We analyzed data from the 2009-2012 Nationwide Inpatient Sample (NIS), containing a representative 20% sample of all hospitalizations in the US. SJS, SJS-TEN and TEN were identified by a validated algorithm using ICD-9-CM codes. Socio-demographics, inflation- adjusted cost, length of stay (LOS), comorbidities and mortality were analyzed using descriptive statistics and multivariate regression analysis. The incidences of SJS, SJS-TEN and TEN were a mean 5.5, 0.8 and 0.4 cases per million children per year, respectively. Prolonged LOS and higher costs of care (SJS: 9.3±0.6 days,