Anetoderma before development of antiphospholipid antibodies: delayed development and monitoring of ...

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" Anetoderma before development of antiphospholipid antibodies: delayed development and monitoring of antiphospholipid antibodies in an SLE patient presenting with anetoderma "
Xia, Fan Di; Hoang, Mai P; Smith, Gideon P

Document Type	:	AL
Record Number	:	924194
Doc. No	:	LA73s8f07w
Language of Document	:	English
Main Entry	:	Xia, Fan Di; Hoang, Mai P; Smith, Gideon P
Title & Author	:	Anetoderma before development of antiphospholipid antibodies: delayed development and monitoring of antiphospholipid antibodies in an SLE patient presenting with anetoderma [Article]\ Xia, Fan Di; Hoang, Mai P; Smith, Gideon P
Title of Periodical	:	Dermatology Online Journal
Volume/ Issue Number	:	23/3
Date	:	2017
Abstract	:	Introduction: Anetoderma is an elastolytic skindisorder that has been associated with the presenceof antiphospholipid antibodies (aPL). Patients withantiphospholipid antibody-positive anetoderma havebeen reported to develop symptoms of Graves disease,antiphospholipid syndrome, and other autoimmuneconditions. The temporal relationship, however,between anetoderma onset and the emergence ofaPL remains unclear, a clarification of which may haveimplications for the screening and monitoring ofpatients with anetoderma. Case: Herein we report acase of a patient with systemic lupus erythematosuspresenting with anetoderma that preceded thedevelopment of aPL. The patient was found to havesubsequently developed IgM cardiolipin antibodiesat a serology follow-up approximately two years later.Conclusion and Relevance: This finding suggests thatanetoderma can precede aPL seroconversion andthat patients with anetoderma may require continuedserology monitoring. Such long-term monitoring willbe important for identifying laboratory indicationsthat may portend the development of furtherautoimmune symptoms associated with anetoderma.