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" Linear IgA bullous dermatosis associated with ulcerative proctitis: treatment challenge "
Yetto, Tatyana; Burns, Carrick
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AL
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| Record Number
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924455
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LA46421332
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| Language of Document
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English
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| Main Entry
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Yetto, Tatyana; Burns, Carrick
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| Title & Author
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Linear IgA bullous dermatosis associated with ulcerative proctitis: treatment challenge [Article]\ Yetto, Tatyana; Burns, Carrick
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| Title of Periodical
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Dermatology Online Journal
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24/7
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| Date
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2018
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| Abstract
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Linear IgA bullous dermatosis is a rare bullous disease in children and adults that can be associated with autoimmune conditions, malignancies, infections, or medication exposure. The definitive diagnosis relies on the biopsy. A 58-year-old man presented to our clinic with a pruritic vesicular and bullous eruption. Histology showed the classic findings of a subepidermal blister with neutrophilic infiltrate and linear IgA deposition along the dermal-epidermal junction. Upon further evaluation, he was diagnosed with ulcerative proctitis. His therapy was complicated owing to side effects and lack of response to the standard treatment options. Dapsone, a first-line therapy, caused symptomatic methemoglobinemia whereas niacinamide with doxycycline were not effective. He required intravenous and oral steroids to reach improvement followed by transitioning to methotrexate.
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