The successful treatment with ixekizumab in a multi-failure psoriasis patient

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" The successful treatment with ixekizumab in a multi-failure psoriasis patient "
Azevedo, Alexandra; Torres, Tiago

Document Type	:	AL
Record Number	:	924493
Doc. No	:	LA2qn1p4bz
Language of Document	:	English
Main Entry	:	Azevedo, Alexandra; Torres, Tiago
Title & Author	:	The successful treatment with ixekizumab in a multi-failure psoriasis patient [Article]\ Azevedo, Alexandra; Torres, Tiago
Title of Periodical	:	Dermatology Online Journal
Volume/ Issue Number	:	24/9
Date	:	2018
Abstract	:	We report a patient with severe psoriasis who failed to respond to phototherapy, conventional systemic treatment and four biologic agents (etanercept, ustekinumab, adalimumab and secukinumab). Combination of a higher-dose secukinumab regimen with phototherapy had no success. Remarkably, ixekizumab, an IL-17A inhibitor, provided almost complete psoriasis clearance after 24 weeks of treatment. The reason for the success of ixekizumab after the failure to respond to a biologic with same mechanism of action is still unknown. Interestingly, failure of secukinumab does not preclude future therapeutic success with a second IL-17A-inhibitor.