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" A pink enlarging plaque on the plantar foot: amelanotic acral lentiginous melanoma "
Okhovat, Jean-Phillip; Tahan, Steven R; Kim, Caroline C
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AL
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| Record Number
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924525
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LA3p91j5db
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| Language of Document
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English
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| Main Entry
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Okhovat, Jean-Phillip; Tahan, Steven R; Kim, Caroline C
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| Title & Author
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A pink enlarging plaque on the plantar foot: amelanotic acral lentiginous melanoma [Article]\ Okhovat, Jean-Phillip; Tahan, Steven R; Kim, Caroline C
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| Title of Periodical
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Dermatology Online Journal
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25/1
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| Date
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2019
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| Abstract
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Acral lentiginous melanomas account for less than 5% of all melanomas, whereas amelanotic melanomas account for around 2-8% of all melanomas. Amelanotic acral lentiginous melanomas are even less common and can often be mistaken for other clinical entities, including pyogenic granulomas, non-melanoma skin cancers, and warts. We describe a man in his 50s with a twenty-year history of a skin-colored plaque on the right plantar foot; after enlargement and failure of wart treatment, a shave biopsy revealed an amelanotic melanoma. A subsequent wide local excision and sentinel lymph node biopsy revealed melanoma in 4 lymph nodes and the patient underwent an abbreviated course of interferon-alpha therapy. The patient remained stable until 2 ? years after diagnosis, at which time he presented with in-transit metastases on the foot and right thigh; he has since been stable on nivolumab. This case represents the challenge of diagnosing amelanotic melanomas on acral surfaces and highlights the importance of considering a skin biopsy for diagnosis of any changing, atypical amelanotic lesions on the feet or hands.
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