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" Apocrine adenocarcinoma in the setting of apocrine hidrocystoma of the leg "
Toyoda, Yoshiko; Franck, Philipp; Brownstone, Nicholas D; Lieberman, Michael; Magro, Cynthia M; Otterburn, David M
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AL
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| Record Number
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924599
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LA1jn1n606
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| Language of Document
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English
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| Main Entry
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Toyoda, Yoshiko; Franck, Philipp; Brownstone, Nicholas D; Lieberman, Michael; Magro, Cynthia M; Otterburn, David M
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| Title & Author
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Apocrine adenocarcinoma in the setting of apocrine hidrocystoma of the leg [Article]\ Toyoda, Yoshiko; Franck, Philipp; Brownstone, Nicholas D; Lieberman, Michael; Magro, Cynthia M; Otterburn, David M
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| Title of Periodical
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Dermatology Online Journal
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25/6
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| Date
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2019
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| Abstract
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Apocrine hidrocystoma is a benign, cystic lesion often presenting in the periorbital region. Apocrine adenocarcinoma is the rare, malignant counterpart occurring mainly in the axilla and anogenital region. There is a paucity of literature on both entities and co-occurrence has been reported in only 5 cases. We present the case of a 48-year-old man with a history of total body irradiation for chronic myelocytic leukemia, diabetes mellitus, and obesity who presented with a calf mass of two years' duration. Epidermal inclusion cyst was presumed and excisional biopsy was carried out. Pathologic analysis revealed apocrine adenocarcinoma in the setting of a precursor apocrine hidrocystoma. Our patient's unique altered immunity and the direct effects of irradiation on the local microenvironment may have resulted in his rare presentation of co-occurrence of apocrine adenocarcinoma within an existing apocrine hidrocystoma. To our knowledge, our patient is the first reported patient with this presentation in the lower extremity.
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