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" A case of porphyria cutanea tarda in the setting of hepatitis C infection and tobacco usage "
Lederhandler, M; Chen, L; Meehan, SA; Brinster, NK; Neimann, A
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AL
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| Record Number
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924686
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LA11p0982m
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| Language of Document
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English
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| Main Entry
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Lederhandler, M; Chen, L; Meehan, SA; Brinster, NK; Neimann, A
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| Title & Author
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A case of porphyria cutanea tarda in the setting of hepatitis C infection and tobacco usage [Article]\ Lederhandler, M; Chen, L; Meehan, SA; Brinster, NK; Neimann, A
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| Title of Periodical
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Dermatology Online Journal
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| Volume/ Issue Number
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25/12
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| Date
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2019
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| Abstract
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Porphyria cutanea tarda (PCT) is the most common type of porphyria, presenting in middle-aged patients with a photodistributed vesiculobullous eruption, milia, and scars. Porphyria cutanea tarda occurs in relation to inhibition of uroporphyrinogen decarboxylase, a key enzyme in the heme biosynthesis pathway. A number of genetic and acquired factors increase susceptibility to PCT by reducing uroporphyrinogen decarboxylase activity. A handful of other vesiculobullous conditions may mimic PCT both clinically and histologically; therefore, both skin biopsy and laboratory evaluation are helpful in confirming the diagnosis. We report a case of PCT in the setting of cigarette usage and untreated hepatitis C infection.
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