Systemic 5-fluorouracil induced lupus erythematosus: a review of the literature

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" Systemic 5-fluorouracil induced lupus erythematosus: a review of the literature "
Shakhbazova, Anastasia; Marsch, Amanda F

Document Type	:	AL
Record Number	:	924691
Doc. No	:	LA3nw0p7hn
Language of Document	:	English
Main Entry	:	Shakhbazova, Anastasia; Marsch, Amanda F
Title & Author	:	Systemic 5-fluorouracil induced lupus erythematosus: a review of the literature [Article]\ Shakhbazova, Anastasia; Marsch, Amanda F
Title of Periodical	:	Dermatology Online Journal
Volume/ Issue Number	:	25/11
Date	:	2019
Abstract	:	Drug-induced subacute cutaneous lupus erythematosus (SCLE) is the most common subtype of drug-induced systemic lupus erythematosus and has been associated with more than 100 drugs. It presents weeks to months after initiation of the culprit medication. The eruption is typically in a photodistribution and it is marked by positive serology to anti-Ro (SSA) antibody. Systemic 5-fluorouracil (5-FU) is a less-common culprit of drug-induced SCLE and its occurrence is likely dependent on exposure to ultraviolet light. Herein, we present a review of drug-induced lupus induced by the pyrimidine analog, 5-FU, and its prodrugs, capecitabine and uracil-tegafur. The search was carried out using the following terms: (PubMed: keywords included drug-induced lupus, 5-fluorouracil, subacute cutaneous lupus erythematosus, capecitabine, uracil-tegafur, discoid lupus, systemic lupus erythematosus).