Ponatinib-induced ichthyosiform drug eruption: insights into acquired ichthyosis

منو

" Ponatinib-induced ichthyosiform drug eruption: insights into acquired ichthyosis "
Xu, Haoming; Busam, Klaus J; Mauro, Michael J; Markova, Alina

Document Type	:	AL
Record Number	:	924755
Doc. No	:	LA2zf9r6vw
Language of Document	:	English
Main Entry	:	Xu, Haoming; Busam, Klaus J; Mauro, Michael J; Markova, Alina
Title & Author	:	Ponatinib-induced ichthyosiform drug eruption: insights into acquired ichthyosis [Article]\ Xu, Haoming; Busam, Klaus J; Mauro, Michael J; Markova, Alina
Title of Periodical	:	Dermatology Online Journal
Volume/ Issue Number	:	23/10
Date	:	2017
Abstract	:	Cutaneous adverse events are commonly experienced with use of tyrosine kinase inhibitors in the treatment of leukemia and typically include nonspecific cutaneous eruptions and xerosis. We report the case of a man who experienced an ichthyosiform drug eruption while taking ponatinib, a third-generation tyrosine kinase inhibitor. Disruption of epidermal growth pathways through inhibition of various receptor tyrosine kinases by ponatinib may offer insights into the pathophysiologic mechanisms behind acquired ichthyosis.