A case of Griscelli syndrome

منو

" A case of Griscelli syndrome "
Kerketta, Joshi Anand; Lodh, Moushumi; Mandal, Krishanu

Document Type	:	AL
Record Number	:	925064
Doc. No	:	LA96f7z0gw
Language of Document	:	English
Main Entry	:	Kerketta, Joshi Anand; Lodh, Moushumi; Mandal, Krishanu
Title & Author	:	A case of Griscelli syndrome [Article]\ Kerketta, Joshi Anand; Lodh, Moushumi; Mandal, Krishanu
Title of Periodical	:	Dermatology Online Journal
Volume/ Issue Number	:	20/11
Date	:	2014
Abstract	:	A hallmark of Griscelli syndrome, a rare autosomal recessive disorder, is hair hypopigmentation characterized by a silver-gray sheen and the presence of large clusters of pigment unevenly distributed in the hair shaft. Either a primary neurological impairment or immune abnormalities are associated with this phenotype. We report the case of a 10-year-old child of consanguineous parents. He presented with abdominal pain and fever and was noted to have silvery hair, eyelashes, and eyebrows. Bone marrow studies indicated hemophagocytosis, whilst microscopic examination of the hair showed irregular agglomerations of pigment in hair shafts. The prognosis, treatment, and genetic counseling needs differ considerably among the various forms of Griscelli Syndrome.