Evolution of the Phosphatase Gene Family Across Nematode Worms and Flies

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" Evolution of the Phosphatase Gene Family Across Nematode Worms and Flies "
Tsai, Paulina; Wilson Sayres, Melissa A.

Document Type	:	AL
Record Number	:	925693
Doc. No	:	LA2sb4992b
Language of Document	:	English
Main Entry	:	Tsai, Paulina; Wilson Sayres, Melissa A.
Title & Author	:	Evolution of the Phosphatase Gene Family Across Nematode Worms and Flies [Article]\ Tsai, Paulina; Wilson Sayres, Melissa A.
Title of Periodical	:	Berkeley Scientific Journal
Volume/ Issue Number	:	18/1
Date	:	2013
Abstract	:	Phosphatase genes have been shown to be involved in male meiosis in the nematode worm, Caenorhabditis elegans, and are expressed in the testis in the fruit fly, Drosophila melanogaster. However, the evolution of this multi-gene family among nematodes and flies had not previously been investigated. We conducted a phylogenetic analysis of all genes in the phosphatase gene family across nematodes and flies using sequences from a 6-way alignment of nematode worms and a 15- way alignment of insects, including 12 Drosophila species. We found that: 1) multiple alignments contain spurious alignments that should be filtered for quality control; 2) several gene sequences with incomplete open reading frames are highly conserved, so may actually be functional genes; and, 3) the phosphatase gene family appears to have expanded independently in the common ancestor of nematodes, and again in the common ancestor of flies (but not all insects).