Fatal Metformin Overdose Presenting with Progressive Hyperglycemia

منو

" Fatal Metformin Overdose Presenting with Progressive Hyperglycemia "
Suchard, Jeffrey R; Grotsky, Thomas A

Document Type	:	AL
Record Number	:	930990
Doc. No	:	LA1nh2f6wn
Language of Document	:	English
Main Entry	:	Suchard, Jeffrey R; Grotsky, Thomas A
Title & Author	:	Fatal Metformin Overdose Presenting with Progressive Hyperglycemia [Article]\ Suchard, Jeffrey R; Grotsky, Thomas A
Title of Periodical	:	Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health
Volume/ Issue Number	:	9/3
Date	:	2008
Abstract	:	A 29-year-old man with no history of diabetes ingested over 60 grams of metformin in a suicide attempt. He presented to the emergency department with acute renal insufficiency, severe lactic acidosis, and rapidly-progressive hyperglycemia. The patient’s peak serum glucose level of 707 mg/dL is the highest yet reported in a case of metformin toxicity. Treatment included sodium bicarbonate infusion and hemodialysis, but the patient suffered several cardiac arrests with pulseless electrical activity and ultimately expired 25 hours after the ingestion.